Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study
BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4)...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.785175/full |
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| author | Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen |
| author_facet | Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen |
| author_sort | Betty Ann Bjerkreim |
| collection | DOAJ |
| description | BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4) substitution.Materials and MethodsTo assess if skin temperature and activation of BAT during treatment with liothyronine (LT3) differs from that of LT4 treatment, fifty-nine female hypothyroid patients with residual symptoms on LT4 or LT4/LT3 combination therapy were randomly assigned in a non-blinded crossover study to receive monotherapy with LT4 or LT3 for 12 weeks each. Change in supraclavicular (SCV) skin temperature overlying BAT, and sternal skin temperature not overlying BAT, during rest and cold stimulation were assessed by infrared thermography (IRT). In addition, abundance of exosomal miR-92a, a biomarker of BAT activation, was estimated as a secondary outcome.ResultsCold stimulated skin temperatures decreased less with LT3 vs. LT4 in both SCV (mean 0.009°C/min [95% CI: 0.004, 0.014]; P<0.001) and sternal areas (mean 0.014°C/min [95% CI: 0.008, 0.020]; P<0.001). No difference in serum exosomal miR-92a abundance was observed between the two treatment groupsConclusionLT3 may reduce dermal heat loss. Thermography data suggested increased BAT activation in hypothyroid patients with cold-intolerance. However, this finding was not corroborated by assessment of the microRNA biomarker of BAT activation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03627611 |
| first_indexed | 2024-12-19T02:25:10Z |
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| id | doaj.art-3b64c8aa8f264c64a5697239faeeaec5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-19T02:25:10Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3b64c8aa8f264c64a5697239faeeaec52022-12-21T20:39:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-11-011210.3389/fendo.2021.785175785175Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover StudyBetty Ann Bjerkreim0Betty Ann Bjerkreim1Sara Salehi Hammerstad2Sara Salehi Hammerstad3Hanne Løvdal Gulseth4Tore Julsrud Berg5Tore Julsrud Berg6Sindre Lee-Ødegård7Anbjørg Rangberg8Christine Monceyron Jonassen9Christine Monceyron Jonassen10Helen Budge11David Morris12James Law13Michael Symonds14Michael Symonds15Erik Fink Eriksen16Erik Fink Eriksen17Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayEndocrinology, Pilestredet Park Specialist Center, Oslo, NorwayDepartment of Pediatrics, Oslo University Hospital, Oslo, NorwayDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Transplantation, Oslo University Hospital, Oslo, NorwayCenter for Laboratory Medicine, Østfold Hospital Trust, Grålum, NorwayCenter for Laboratory Medicine, Østfold Hospital Trust, Grålum, NorwayDepartment of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, NorwayAcademic Child Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom0Bioengineering Research Group, Faculty of Engineering, University of Nottingham, Nottingham, United KingdomAcademic Child Health, School of Medicine, University of Nottingham, Nottingham, United KingdomAcademic Child Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom1Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United KingdomEndocrinology, Pilestredet Park Specialist Center, Oslo, Norway2The Faculty of Dentistry, University of Oslo, Oslo, NorwayBackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation. Nevertheless, persistent cold-intolerance exists among a substantial proportion of hypothyroid patients on adequate levothyroxine (LT4) substitution.Materials and MethodsTo assess if skin temperature and activation of BAT during treatment with liothyronine (LT3) differs from that of LT4 treatment, fifty-nine female hypothyroid patients with residual symptoms on LT4 or LT4/LT3 combination therapy were randomly assigned in a non-blinded crossover study to receive monotherapy with LT4 or LT3 for 12 weeks each. Change in supraclavicular (SCV) skin temperature overlying BAT, and sternal skin temperature not overlying BAT, during rest and cold stimulation were assessed by infrared thermography (IRT). In addition, abundance of exosomal miR-92a, a biomarker of BAT activation, was estimated as a secondary outcome.ResultsCold stimulated skin temperatures decreased less with LT3 vs. LT4 in both SCV (mean 0.009°C/min [95% CI: 0.004, 0.014]; P<0.001) and sternal areas (mean 0.014°C/min [95% CI: 0.008, 0.020]; P<0.001). No difference in serum exosomal miR-92a abundance was observed between the two treatment groupsConclusionLT3 may reduce dermal heat loss. Thermography data suggested increased BAT activation in hypothyroid patients with cold-intolerance. However, this finding was not corroborated by assessment of the microRNA biomarker of BAT activation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03627611https://www.frontiersin.org/articles/10.3389/fendo.2021.785175/fullhypothyroidismbrown adipose tissue (BAT)cold-induced thermogenesisinfrared thermographyliothyroninelevothyroxine |
| spellingShingle | Betty Ann Bjerkreim Betty Ann Bjerkreim Sara Salehi Hammerstad Sara Salehi Hammerstad Hanne Løvdal Gulseth Tore Julsrud Berg Tore Julsrud Berg Sindre Lee-Ødegård Anbjørg Rangberg Christine Monceyron Jonassen Christine Monceyron Jonassen Helen Budge David Morris James Law Michael Symonds Michael Symonds Erik Fink Eriksen Erik Fink Eriksen Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study Frontiers in Endocrinology hypothyroidism brown adipose tissue (BAT) cold-induced thermogenesis infrared thermography liothyronine levothyroxine |
| title | Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_full | Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_fullStr | Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_full_unstemmed | Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_short | Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study |
| title_sort | effect of liothyronine treatment on dermal temperature and activation of brown adipose tissue in female hypothyroid patients a randomized crossover study |
| topic | hypothyroidism brown adipose tissue (BAT) cold-induced thermogenesis infrared thermography liothyronine levothyroxine |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.785175/full |
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