A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging
Transillumination with non-ionizing radiation followed by the observation of transmitted and diffused light is the simplest, and probably the oldest method to obtain qualitative information on the internal structure of tissues or body sections. Although scattering precludes formation of high-definit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/19/4/851 |
| _version_ | 1811187320895832064 |
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| author | Sabina Merlo Valentina Bello Elisabetta Bodo Sara Pizzurro |
| author_facet | Sabina Merlo Valentina Bello Elisabetta Bodo Sara Pizzurro |
| author_sort | Sabina Merlo |
| collection | DOAJ |
| description | Transillumination with non-ionizing radiation followed by the observation of transmitted and diffused light is the simplest, and probably the oldest method to obtain qualitative information on the internal structure of tissues or body sections. Although scattering precludes formation of high-definition image (unless complex techniques are employed), low resolution pictures complemented by information on the functional condition of the living sample can be extracted. In this context, we have investigated a portable optoelectronic instrumental configuration for efficient transillumination and image detection, even in ambient day-light, of in vivo samples with thickness up to 5 cm, sufficient for visualizing macroscopic structures. Tissue illumination is obtained with an extended source consisting in a matrix of 36 near infrared Vertical Cavity Surface Emitting Lasers (VCSELs) that is powered by a custom designed low-voltage current driver. In addition to the successful acquisition of morphological images of the hand dorsal vein pattern, functional detection of physiological parameters (breath and hearth rate) is achieved non-invasively by means of a monochrome camera, with a Complementary Metal Oxide Semiconductor (CMOS) sensor, turned into a wavelength selective image detector using narrow-band optical filtering. |
| first_indexed | 2024-04-11T14:00:11Z |
| format | Article |
| id | doaj.art-3b6621e9f5e943bdaf92ca6a68308447 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T14:00:11Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-3b6621e9f5e943bdaf92ca6a683084472022-12-22T04:20:08ZengMDPI AGSensors1424-82202019-02-0119485110.3390/s19040851s19040851A VCSEL-Based NIR Transillumination System for Morpho-Functional ImagingSabina Merlo0Valentina Bello1Elisabetta Bodo2Sara Pizzurro3Dipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, 27100 Pavia, ItalyDipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, 27100 Pavia, ItalyDipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, 27100 Pavia, ItalyDipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, 27100 Pavia, ItalyTransillumination with non-ionizing radiation followed by the observation of transmitted and diffused light is the simplest, and probably the oldest method to obtain qualitative information on the internal structure of tissues or body sections. Although scattering precludes formation of high-definition image (unless complex techniques are employed), low resolution pictures complemented by information on the functional condition of the living sample can be extracted. In this context, we have investigated a portable optoelectronic instrumental configuration for efficient transillumination and image detection, even in ambient day-light, of in vivo samples with thickness up to 5 cm, sufficient for visualizing macroscopic structures. Tissue illumination is obtained with an extended source consisting in a matrix of 36 near infrared Vertical Cavity Surface Emitting Lasers (VCSELs) that is powered by a custom designed low-voltage current driver. In addition to the successful acquisition of morphological images of the hand dorsal vein pattern, functional detection of physiological parameters (breath and hearth rate) is achieved non-invasively by means of a monochrome camera, with a Complementary Metal Oxide Semiconductor (CMOS) sensor, turned into a wavelength selective image detector using narrow-band optical filtering.https://www.mdpi.com/1424-8220/19/4/851transilluminationVCSELnear infrared radiationnon-ionizing radiationtissue imagingnon-invasive morpho-functional imaging |
| spellingShingle | Sabina Merlo Valentina Bello Elisabetta Bodo Sara Pizzurro A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging Sensors transillumination VCSEL near infrared radiation non-ionizing radiation tissue imaging non-invasive morpho-functional imaging |
| title | A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging |
| title_full | A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging |
| title_fullStr | A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging |
| title_full_unstemmed | A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging |
| title_short | A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging |
| title_sort | vcsel based nir transillumination system for morpho functional imaging |
| topic | transillumination VCSEL near infrared radiation non-ionizing radiation tissue imaging non-invasive morpho-functional imaging |
| url | https://www.mdpi.com/1424-8220/19/4/851 |
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