Anticonvulsant Effect of Carbenoxolone on Chronic Epileptic Rats and Its Mechanism Related to Connexin and High-Frequency Oscillations

Anticonvulsant Effect of Carbenoxolone on Chronic Epileptic Rats and Its Mechanism Related to Connexin and High-Frequency Oscillations

ObjectiveThis study was designed to investigate the influence and mechanism of gap junction carbenoxolone (CBX) on dynamic changes in the spectral power of ripples and fast ripples (FRs) in the hippocampus of chronic epileptic rats.MethodsThe lithium-pilocarpine (PILO) status epilepticus (SE) model...

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Bibliographic Details
Main Authors: Benke Liu, Xiao Ran, Yanjun Yi, Xinyu Zhang, Hengsheng Chen, Yue Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
carbenoxolone
chronic epilepsy
connexin
ripples
fast ripples
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.870947/full

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