Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage

Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage

ABSTRACTCisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug in clinical practice and is known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role in cisplatin's inner ear toxi...

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Bibliographic Details
Main Authors: Jintao Lou, Fan Wu, Wuhui He, Rui Hu, Ziyi Cai, Guisheng Chen, Wenji Zhao, Zhigang Zhang, Yu Si
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Redox Report
Subjects:
Cisplatin
hesperidin
Nrf2
ROS
apoptosis
hearing loss
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2024.2341470

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