A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis
Peritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with dialysis inadequacy and ultrafiltration failu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1220450/full |
| _version_ | 1797674327734222848 |
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| author | Jin’e Li Jin’e Li Yinghong Liu Jianping Liu |
| author_facet | Jin’e Li Jin’e Li Yinghong Liu Jianping Liu |
| author_sort | Jin’e Li |
| collection | DOAJ |
| description | Peritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with dialysis inadequacy and ultrafiltration failure. The exact mechanism and aetiology of ultrafiltration failure have been of great concern, with triggers such as biological incompatibility of peritoneal dialysis solutions, uraemia toxins, and recurrent intraperitoneal inflammation initiating multiple pathways that regulate the release of various cytokines, promote the transcription of fibrosis-related genes, and deposit extracellular matrix. As a result, peritoneal fibrosis occurs. Exploring the pathogenic factors and molecular mechanisms can help us prevent peritoneal fibrosis and prolong the duration of Peritoneal dialysis. |
| first_indexed | 2024-03-11T21:57:29Z |
| format | Article |
| id | doaj.art-3b69569425f7464ba701d6f1dafeedbd |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-11T21:57:29Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-3b69569425f7464ba701d6f1dafeedbd2023-09-26T01:37:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-09-011410.3389/fphys.2023.12204501220450A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysisJin’e Li0Jin’e Li1Yinghong Liu2Jianping Liu3Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaPeritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with dialysis inadequacy and ultrafiltration failure. The exact mechanism and aetiology of ultrafiltration failure have been of great concern, with triggers such as biological incompatibility of peritoneal dialysis solutions, uraemia toxins, and recurrent intraperitoneal inflammation initiating multiple pathways that regulate the release of various cytokines, promote the transcription of fibrosis-related genes, and deposit extracellular matrix. As a result, peritoneal fibrosis occurs. Exploring the pathogenic factors and molecular mechanisms can help us prevent peritoneal fibrosis and prolong the duration of Peritoneal dialysis.https://www.frontiersin.org/articles/10.3389/fphys.2023.1220450/fullperitoneal dialysisperitoneal fibrosisEMTTGF-β1mechanism |
| spellingShingle | Jin’e Li Jin’e Li Yinghong Liu Jianping Liu A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis Frontiers in Physiology peritoneal dialysis peritoneal fibrosis EMT TGF-β1 mechanism |
| title | A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| title_full | A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| title_fullStr | A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| title_full_unstemmed | A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| title_short | A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| title_sort | review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis |
| topic | peritoneal dialysis peritoneal fibrosis EMT TGF-β1 mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1220450/full |
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