Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver
Abstract The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44814-z |
| _version_ | 1797452709086887936 |
|---|---|
| author | Mariam Salameh Sukaina Zeitoun-Ghandour Lina Sabra Ahmad Daher Mahmoud Khalil Wissam H. Joumaa |
| author_facet | Mariam Salameh Sukaina Zeitoun-Ghandour Lina Sabra Ahmad Daher Mahmoud Khalil Wissam H. Joumaa |
| author_sort | Mariam Salameh |
| collection | DOAJ |
| description | Abstract The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague–Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves. |
| first_indexed | 2024-03-09T15:12:34Z |
| format | Article |
| id | doaj.art-3b6b3536e6dc4e91849ef4690e019bc7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:12:34Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3b6b3536e6dc4e91849ef4690e019bc72023-11-26T13:15:22ZengNature PortfolioScientific Reports2045-23222023-10-0113111410.1038/s41598-023-44814-zImpact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liverMariam Salameh0Sukaina Zeitoun-Ghandour1Lina Sabra2Ahmad Daher3Mahmoud Khalil4Wissam H. Joumaa5Department of Biological Sciences, Faculty of Science, Beirut Arab UniversityRammal Hassan Rammal Research Laboratory, PhyToxE Research Group, Faculty of Sciences Section V, Lebanese UniversityRammal Hassan Rammal Research Laboratory, PhyToxE Research Group, Faculty of Sciences Section V, Lebanese UniversityRammal Hassan Rammal Research Laboratory, ATAC Research Group, Faculty of Sciences (I), Lebanese UniversityDepartment of Biological Sciences, Faculty of Science, Beirut Arab UniversityRammal Hassan Rammal Research Laboratory, PhyToxE Research Group, Faculty of Sciences Section V, Lebanese UniversityAbstract The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague–Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.https://doi.org/10.1038/s41598-023-44814-z |
| spellingShingle | Mariam Salameh Sukaina Zeitoun-Ghandour Lina Sabra Ahmad Daher Mahmoud Khalil Wissam H. Joumaa Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver Scientific Reports |
| title | Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver |
| title_full | Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver |
| title_fullStr | Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver |
| title_full_unstemmed | Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver |
| title_short | Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver |
| title_sort | impact of gsm emw exposure on the markers of oxidative stress in fetal rat liver |
| url | https://doi.org/10.1038/s41598-023-44814-z |
| work_keys_str_mv | AT mariamsalameh impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver AT sukainazeitounghandour impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver AT linasabra impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver AT ahmaddaher impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver AT mahmoudkhalil impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver AT wissamhjoumaa impactofgsmemwexposureonthemarkersofoxidativestressinfetalratliver |