Process development and validation of expanded regulatory T cells for prospective applications: an example of manufacturing a personalized advanced therapy medicinal product

Process development and validation of expanded regulatory T cells for prospective applications: an example of manufacturing a personalized advanced therapy medicinal product

Abstract Background A growing number of clinical trials have shown that regulatory T (Treg) cell transfer may have a favorable effect on the maintenance of self-tolerance and immune homeostasis in different conditions such as graft-versus-host disease (GvHD), solid organ transplantation, type 1 diab...

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Bibliographic Details
Main Authors: Cristiana Lavazza, Silvia Budelli, Elisa Montelatici, Mariele Viganò, Francesca Ulbar, Lucia Catani, Marta Giulia Cannone, Sara Savelli, Elisa Groppelli, Lorenza Lazzari, Roberto M. Lemoli, Matteo Cescon, Gaetano La Manna, Rosaria Giordano, Tiziana Montemurro
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Translational Medicine
Subjects:
ATMP
GMP process development
Process validation
Online Access:https://doi.org/10.1186/s12967-021-03200-x

Internet

https://doi.org/10.1186/s12967-021-03200-x

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