Research Progress on the Anti-Aging Potential of the Active Components of Ginseng
Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Aging increases β-galactosidase activity, enhances cell sprea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3286 |
| _version_ | 1797586220684935168 |
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| author | Jingqian Su Qiaofen Su Shan Hu Xinglin Ruan Songying Ouyang |
| author_facet | Jingqian Su Qiaofen Su Shan Hu Xinglin Ruan Songying Ouyang |
| author_sort | Jingqian Su |
| collection | DOAJ |
| description | Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Aging increases β-galactosidase activity, enhances cell spreading, and induces Lamin B1 loss, which further accelerate the aging process. It is associated with a variety of diseases, such as Alzheimer’s disease, Parkinson’s, type 2 diabetes, and chronic inflammation. Ginseng is a traditional Chinese medicine with anti-aging effects. The active components of ginseng, including saponins, polysaccharides, and active peptides, have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. DNA damage is the main factor associated with aging, and the mechanism through which the active ingredients of ginseng reduce DNA damage and delay aging has not been comprehensively described. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng. Furthermore, it broadens the scope of ideas for further research on natural products and aging. |
| first_indexed | 2024-03-11T00:19:22Z |
| format | Article |
| id | doaj.art-3b6e4f40c3a84dd1b4c124cea2110a2e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:22Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3b6e4f40c3a84dd1b4c124cea2110a2e2023-11-18T23:22:30ZengMDPI AGNutrients2072-66432023-07-011515328610.3390/nu15153286Research Progress on the Anti-Aging Potential of the Active Components of GinsengJingqian Su0Qiaofen Su1Shan Hu2Xinglin Ruan3Songying Ouyang4Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, ChinaAging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Aging increases β-galactosidase activity, enhances cell spreading, and induces Lamin B1 loss, which further accelerate the aging process. It is associated with a variety of diseases, such as Alzheimer’s disease, Parkinson’s, type 2 diabetes, and chronic inflammation. Ginseng is a traditional Chinese medicine with anti-aging effects. The active components of ginseng, including saponins, polysaccharides, and active peptides, have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. DNA damage is the main factor associated with aging, and the mechanism through which the active ingredients of ginseng reduce DNA damage and delay aging has not been comprehensively described. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng. Furthermore, it broadens the scope of ideas for further research on natural products and aging.https://www.mdpi.com/2072-6643/15/15/3286ginsengagingDNA damageDNA repair |
| spellingShingle | Jingqian Su Qiaofen Su Shan Hu Xinglin Ruan Songying Ouyang Research Progress on the Anti-Aging Potential of the Active Components of Ginseng Nutrients ginseng aging DNA damage DNA repair |
| title | Research Progress on the Anti-Aging Potential of the Active Components of Ginseng |
| title_full | Research Progress on the Anti-Aging Potential of the Active Components of Ginseng |
| title_fullStr | Research Progress on the Anti-Aging Potential of the Active Components of Ginseng |
| title_full_unstemmed | Research Progress on the Anti-Aging Potential of the Active Components of Ginseng |
| title_short | Research Progress on the Anti-Aging Potential of the Active Components of Ginseng |
| title_sort | research progress on the anti aging potential of the active components of ginseng |
| topic | ginseng aging DNA damage DNA repair |
| url | https://www.mdpi.com/2072-6643/15/15/3286 |
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