Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy
Abstract Intrahepatic cholestasis of pregnancy is a disorder characterized by pruritus and elevated liver function tests and bile acids. Poor vitamin absorption and, as a result, hypovitaminosis K can occur as a result of the pathology. Given the known effects of vitamin K, the authors considered th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-022-04875-w |
| _version_ | 1818234267428192256 |
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| author | Maria Cemortan Irina Sagaidac Olga Cernetchi |
| author_facet | Maria Cemortan Irina Sagaidac Olga Cernetchi |
| author_sort | Maria Cemortan |
| collection | DOAJ |
| description | Abstract Intrahepatic cholestasis of pregnancy is a disorder characterized by pruritus and elevated liver function tests and bile acids. Poor vitamin absorption and, as a result, hypovitaminosis K can occur as a result of the pathology. Given the known effects of vitamin K, the authors considered that hypovitaminosis K could increase the risk of coagulopathic hemorrhage in pregnant women. The study revealed that 59.2% of women with intrahepatic cholestasis of pregnancy were diagnosed with hypovitaminosis K; however, 98.6% of women had normal coagulogram indices. Thus, coagulogram markers are more likely to indicate vitamin K activity than its actual level. |
| first_indexed | 2024-12-12T11:35:22Z |
| format | Article |
| id | doaj.art-3b70b7f256ce41399447b699fc74597e |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-12T11:35:22Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-3b70b7f256ce41399447b699fc74597e2022-12-22T00:25:40ZengBMCBMC Pregnancy and Childbirth1471-23932022-07-012211610.1186/s12884-022-04875-wAssessment of vitamin K levels in women with intrahepatic cholestasis of pregnancyMaria Cemortan0Irina Sagaidac1Olga Cernetchi2Department of Obstetrics and Gynecology, Nicolae Testemitanu State University of Medicine and PharmacyDepartment of Obstetrics and Gynecology, Nicolae Testemitanu State University of Medicine and PharmacyDepartment of Obstetrics and Gynecology, Nicolae Testemitanu State University of Medicine and PharmacyAbstract Intrahepatic cholestasis of pregnancy is a disorder characterized by pruritus and elevated liver function tests and bile acids. Poor vitamin absorption and, as a result, hypovitaminosis K can occur as a result of the pathology. Given the known effects of vitamin K, the authors considered that hypovitaminosis K could increase the risk of coagulopathic hemorrhage in pregnant women. The study revealed that 59.2% of women with intrahepatic cholestasis of pregnancy were diagnosed with hypovitaminosis K; however, 98.6% of women had normal coagulogram indices. Thus, coagulogram markers are more likely to indicate vitamin K activity than its actual level.https://doi.org/10.1186/s12884-022-04875-wIntrahepatic cholestasis of pregnancyObstetric cholestasisICPPregnancy |
| spellingShingle | Maria Cemortan Irina Sagaidac Olga Cernetchi Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy BMC Pregnancy and Childbirth Intrahepatic cholestasis of pregnancy Obstetric cholestasis ICP Pregnancy |
| title | Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy |
| title_full | Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy |
| title_fullStr | Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy |
| title_full_unstemmed | Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy |
| title_short | Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy |
| title_sort | assessment of vitamin k levels in women with intrahepatic cholestasis of pregnancy |
| topic | Intrahepatic cholestasis of pregnancy Obstetric cholestasis ICP Pregnancy |
| url | https://doi.org/10.1186/s12884-022-04875-w |
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