Dose‐Dependent Carbon‐Dot‐Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism

Dose‐Dependent Carbon‐Dot‐Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism

Abstract Uveal melanoma (UM) is the most common intraocular malignant tumor in adults and has a low survival rate following metastasis; it is derived from melanocytes susceptible to reactive oxygen species (ROS). Carbon dot (Cdot) nanoparticles are a promising tool in cancer detection and therapy du...

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Bibliographic Details
Main Authors: Yi Ding, Jie Yu, Xingyu Chen, Shaoyun Wang, Zhaoxu Tu, Guangxia Shen, Huixue Wang, Renbing Jia, Shengfang Ge, Jing Ruan, Kam W. Leong, Xianqun Fan
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Advanced Science
Subjects:
glutamine
metabolomics
mTOR
ROS
uveal melanoma
Online Access:https://doi.org/10.1002/advs.202002404

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