Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis
Osteoarthritis (OA) is a heterogeneous disease with varying degrees of inflammatory responses, structural changes, functional insufficiency, and disease progression as a whole. Some OA phenotypes are characterized by a high local inflammatory response, persistent pain, persistent synovitis, and seve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2019-05-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/916 |
| _version_ | 1797876737135083520 |
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| author | S. G. Anikin L. I. Alekseeva A. M. Lila |
| author_facet | S. G. Anikin L. I. Alekseeva A. M. Lila |
| author_sort | S. G. Anikin |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a heterogeneous disease with varying degrees of inflammatory responses, structural changes, functional insufficiency, and disease progression as a whole. Some OA phenotypes are characterized by a high local inflammatory response, persistent pain, persistent synovitis, and severe functional limitation. As a rule, the use of traditional nonsteroidal anti-inflammatory drugs in these patients and the injection of glucocorticoids into the joint show no substantial effect. Taking into account the important role of inflammation and the involvement of immune responses in the pathogenesis of OA, the existence of its erosive forms, the use of some disease-modifying anti-rheumatic drugs could be a rational solution of the problem in the therapy of this disease.The paper reviews data on the efficiency and safety of using methotrexate and hydroxychloroquine in OA. |
| first_indexed | 2024-04-10T02:06:11Z |
| format | Article |
| id | doaj.art-3b72c899fdef4494b0f0611465df0c32 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:06:11Z |
| publishDate | 2019-05-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-3b72c899fdef4494b0f0611465df0c322023-03-13T08:39:26ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2019-05-01132909510.14412/1996-7012-2019-2-90-952173Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritisS. G. Anikin0L. I. Alekseeva1A. M. Lila2ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Osteoarthritis (OA) is a heterogeneous disease with varying degrees of inflammatory responses, structural changes, functional insufficiency, and disease progression as a whole. Some OA phenotypes are characterized by a high local inflammatory response, persistent pain, persistent synovitis, and severe functional limitation. As a rule, the use of traditional nonsteroidal anti-inflammatory drugs in these patients and the injection of glucocorticoids into the joint show no substantial effect. Taking into account the important role of inflammation and the involvement of immune responses in the pathogenesis of OA, the existence of its erosive forms, the use of some disease-modifying anti-rheumatic drugs could be a rational solution of the problem in the therapy of this disease.The paper reviews data on the efficiency and safety of using methotrexate and hydroxychloroquine in OA.https://mrj.ima-press.net/mrj/article/view/916остеоартритметотрексатгидроксихлорохин |
| spellingShingle | S. G. Anikin L. I. Alekseeva A. M. Lila Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis Современная ревматология остеоартрит метотрексат гидроксихлорохин |
| title | Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis |
| title_full | Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis |
| title_fullStr | Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis |
| title_full_unstemmed | Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis |
| title_short | Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis |
| title_sort | use of disease modifying anti rheumatic drugs in the therapy of osteoarthritis |
| topic | остеоартрит метотрексат гидроксихлорохин |
| url | https://mrj.ima-press.net/mrj/article/view/916 |
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