Global health trials methodological research agenda: results from a priority setting exercise
Abstract Background Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities, however, may not be reflected in the needs of s...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-02-01
|
| Series: | Trials |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13063-018-2440-y |
| _version_ | 1818419375482339328 |
|---|---|
| author | Anna Rosala-Hallas Aneel Bhangu Jane Blazeby Louise Bowman Mike Clarke Trudie Lang Mona Nasser Nandi Siegfried Karla Soares-Weiser Matt R. Sydes Duolao Wang Junhua Zhang Paula R. Williamson |
| author_facet | Anna Rosala-Hallas Aneel Bhangu Jane Blazeby Louise Bowman Mike Clarke Trudie Lang Mona Nasser Nandi Siegfried Karla Soares-Weiser Matt R. Sydes Duolao Wang Junhua Zhang Paula R. Williamson |
| author_sort | Anna Rosala-Hallas |
| collection | DOAJ |
| description | Abstract Background Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities, however, may not be reflected in the needs of similar research in low- to middle-income countries (LMICs) with different healthcare provision, resources and research infrastructure. The aim of the study was to identify the top priorities for methodological research in LMICs to inform further research and ultimately to improve clinical trials in these regions. Methods An online, two-round survey was conducted from December 2016 to April 2017 amongst researchers and methodologists working on trials in LMICs. The first round required participants to suggest between three and six topics which they felt were priorities for trial methodological research in LMICs. The second round invited participants to grade the importance of a compulsory list of topics suggested by four or more individuals, and an optional list of the remaining topics. Findings Rounds 1 and 2 were completed by 412 and 314 participants, respectively. A wide spread of years of experience, discipline, current country of residence, origin of trials training and area of involvement in trials was reported. The topics deemed most important for methodological research were: choosing appropriate outcomes to measure and training of research staff. Conclusion By presenting these top priorities we have the foundations of a global health trials methodological research agenda which we hope will foster future research in specific areas in order to increase and improve trials in LMICs. |
| first_indexed | 2024-12-14T12:37:34Z |
| format | Article |
| id | doaj.art-3b752f64620e47ce9847e136cd227f2e |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-14T12:37:34Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-3b752f64620e47ce9847e136cd227f2e2022-12-21T23:00:59ZengBMCTrials1745-62152018-02-011911810.1186/s13063-018-2440-yGlobal health trials methodological research agenda: results from a priority setting exerciseAnna Rosala-Hallas0Aneel Bhangu1Jane Blazeby2Louise Bowman3Mike Clarke4Trudie Lang5Mona Nasser6Nandi Siegfried7Karla Soares-Weiser8Matt R. Sydes9Duolao Wang10Junhua Zhang11Paula R. Williamson12Clinical Trials Research Centre, Biostatistics, University of LiverpoolAcademic Department of Surgery, Queen Elizabeth HospitalMedical Research Council ConDuCT II Hub for Trials Methodology Research, School of Social and Community Medicine, University of BristolClinical Trial Service Unit, Nuffield Department of Population Health, University of OxfordNorthern Ireland Network for Trials Methodology Research, Queen’s University BelfastThe Global Health Network, Centre for Tropical Medicine and Global Health, University of OxfordPeninsula Dental School, Plymouth UniversitySouth African Medical Research CouncilCochraneMedical Research Council Clinical Trials Unit at University College LondonLiverpool School of Tropical MedicineEvidence Based Medicine Centre, Tianjin University of Traditional Chinese MedicineNorth West Hub for Trials Methodology Research/Clinical Trials Research Centre, University of LiverpoolAbstract Background Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities, however, may not be reflected in the needs of similar research in low- to middle-income countries (LMICs) with different healthcare provision, resources and research infrastructure. The aim of the study was to identify the top priorities for methodological research in LMICs to inform further research and ultimately to improve clinical trials in these regions. Methods An online, two-round survey was conducted from December 2016 to April 2017 amongst researchers and methodologists working on trials in LMICs. The first round required participants to suggest between three and six topics which they felt were priorities for trial methodological research in LMICs. The second round invited participants to grade the importance of a compulsory list of topics suggested by four or more individuals, and an optional list of the remaining topics. Findings Rounds 1 and 2 were completed by 412 and 314 participants, respectively. A wide spread of years of experience, discipline, current country of residence, origin of trials training and area of involvement in trials was reported. The topics deemed most important for methodological research were: choosing appropriate outcomes to measure and training of research staff. Conclusion By presenting these top priorities we have the foundations of a global health trials methodological research agenda which we hope will foster future research in specific areas in order to increase and improve trials in LMICs.http://link.springer.com/article/10.1186/s13063-018-2440-yTrials methodologyPriority settingGlobal health |
| spellingShingle | Anna Rosala-Hallas Aneel Bhangu Jane Blazeby Louise Bowman Mike Clarke Trudie Lang Mona Nasser Nandi Siegfried Karla Soares-Weiser Matt R. Sydes Duolao Wang Junhua Zhang Paula R. Williamson Global health trials methodological research agenda: results from a priority setting exercise Trials Trials methodology Priority setting Global health |
| title | Global health trials methodological research agenda: results from a priority setting exercise |
| title_full | Global health trials methodological research agenda: results from a priority setting exercise |
| title_fullStr | Global health trials methodological research agenda: results from a priority setting exercise |
| title_full_unstemmed | Global health trials methodological research agenda: results from a priority setting exercise |
| title_short | Global health trials methodological research agenda: results from a priority setting exercise |
| title_sort | global health trials methodological research agenda results from a priority setting exercise |
| topic | Trials methodology Priority setting Global health |
| url | http://link.springer.com/article/10.1186/s13063-018-2440-y |
| work_keys_str_mv | AT annarosalahallas globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT aneelbhangu globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT janeblazeby globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT louisebowman globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT mikeclarke globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT trudielang globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT monanasser globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT nandisiegfried globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT karlasoaresweiser globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT mattrsydes globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT duolaowang globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT junhuazhang globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise AT paularwilliamson globalhealthtrialsmethodologicalresearchagendaresultsfromaprioritysettingexercise |