Occupational risk factors for Parkinson's disease: a case-control study in Japan
<p>Abstract</p> <p>Background</p> <p>The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.</p> <p>Methods<...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-07-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/11/83 |
| _version_ | 1818757757275209728 |
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| author | Kawamura Nobutoshi Miki Takami Oeda Tomoko Yamada Tatsuo Tsuboi Yoshio Kiyohara Chikako Sasaki Satoshi Fukushima Wakaba Miyake Yoshihiro Tanaka Keiko Sakae Nobutaka Fukuyama Hidenao Hirota Yoshio Nagai Masaki |
| author_facet | Kawamura Nobutoshi Miki Takami Oeda Tomoko Yamada Tatsuo Tsuboi Yoshio Kiyohara Chikako Sasaki Satoshi Fukushima Wakaba Miyake Yoshihiro Tanaka Keiko Sakae Nobutaka Fukuyama Hidenao Hirota Yoshio Nagai Masaki |
| author_sort | Kawamura Nobutoshi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.</p> <p>Methods</p> <p>We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.</p> <p>Results</p> <p>Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95% CI: 0.32-1.06, <it>P </it>= 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95% CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (<it>P </it>= 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95% CI: 0.56-14.86) and 1.74 (95% CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.</p> <p>Conclusion</p> <p>The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.</p> |
| first_indexed | 2024-12-18T06:16:00Z |
| format | Article |
| id | doaj.art-3b7538217f7c457fbe5b46f9ad3b862c |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-18T06:16:00Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-3b7538217f7c457fbe5b46f9ad3b862c2022-12-21T21:18:15ZengBMCBMC Neurology1471-23772011-07-011118310.1186/1471-2377-11-83Occupational risk factors for Parkinson's disease: a case-control study in JapanKawamura NobutoshiMiki TakamiOeda TomokoYamada TatsuoTsuboi YoshioKiyohara ChikakoSasaki SatoshiFukushima WakabaMiyake YoshihiroTanaka KeikoSakae NobutakaFukuyama HidenaoHirota YoshioNagai Masaki<p>Abstract</p> <p>Background</p> <p>The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan.</p> <p>Methods</p> <p>We examined 249 cases within 6 years of onset of PD. Control subjects were 369 inpatients and outpatients without neurodegenerative disease. Information on occupational factors was obtained from a self-administered questionnaire. Relative risks of PD were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) based on logistic regression. Adjustments were made for gender, age, region of residence, educational level, and pack-years of smoking.</p> <p>Results</p> <p>Working in a professional or technical occupation tended to be inversely related to the risk of PD: adjusted OR was 0.59 (95% CI: 0.32-1.06, <it>P </it>= 0.08). According to a stratified analysis by gender, the decreased risk of PD for persons in professional or technical occupations was statistically significant only for men. Adjusted ORs for a professional or technical occupation among men and women were 0.22 (95% CI: 0.06-0.67) and 0.99 (0.47-2.07), respectively, and significant interaction was observed (<it>P </it>= 0.048 for homogeneity of OR). In contrast, risk estimates for protective service occupations and transport or communications were increased, although the results were not statistically significant: adjusted ORs were 2.73 (95% CI: 0.56-14.86) and 1.74 (95% CI: 0.65-4.74), respectively. No statistical significance was seen in data concerning exposure to occupational agents and the risk of PD, although roughly a 2-fold increase in OR was observed for workers exposed to stone or sand.</p> <p>Conclusion</p> <p>The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD.</p>http://www.biomedcentral.com/1471-2377/11/83 |
| spellingShingle | Kawamura Nobutoshi Miki Takami Oeda Tomoko Yamada Tatsuo Tsuboi Yoshio Kiyohara Chikako Sasaki Satoshi Fukushima Wakaba Miyake Yoshihiro Tanaka Keiko Sakae Nobutaka Fukuyama Hidenao Hirota Yoshio Nagai Masaki Occupational risk factors for Parkinson's disease: a case-control study in Japan BMC Neurology |
| title | Occupational risk factors for Parkinson's disease: a case-control study in Japan |
| title_full | Occupational risk factors for Parkinson's disease: a case-control study in Japan |
| title_fullStr | Occupational risk factors for Parkinson's disease: a case-control study in Japan |
| title_full_unstemmed | Occupational risk factors for Parkinson's disease: a case-control study in Japan |
| title_short | Occupational risk factors for Parkinson's disease: a case-control study in Japan |
| title_sort | occupational risk factors for parkinson s disease a case control study in japan |
| url | http://www.biomedcentral.com/1471-2377/11/83 |
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