Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19
This study aimed to achieve a better understanding of the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease 2019 (COVID-19). We searched PubMed and Embase between December 2019 and March 2021 and included only peer-rev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/13/2953 |
| _version_ | 1797528120264228864 |
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| author | Tzu-Chen Lo Yu-Yen Chen |
| author_facet | Tzu-Chen Lo Yu-Yen Chen |
| author_sort | Tzu-Chen Lo |
| collection | DOAJ |
| description | This study aimed to achieve a better understanding of the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease 2019 (COVID-19). We searched PubMed and Embase between December 2019 and March 2021 and included only peer-reviewed clinical studies or case series. The proportions of patients who had conjunctivitis, systemic symptoms/signs (s/s), Kawasaki disease (KD), and exposure history to suspected/confirmed COVID-19 cases were obtained. Moreover, positive rates of the nasopharyngeal real-time reverse transcriptase polymerase chain reaction (RT-PCR) and serum antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recorded. Overall, 32 studies with 1458 patients were included in the pooled analysis. Around half of the patients had conjunctivitis. The five most common systemic manifestations were fever (96.4%), gastrointestinal s/s (76.7%), shock (61.5%), rash (57.1%), and neurological s/s (36.8%). Almost one-third presented complete KD and about half had exposure history to COVID-19 cases. The positivity of the serology (82.2%) was higher than that of the nasopharyngeal RT-PCR (37.0%). MIS-C associated with COVID-19 leads to several features similar to KD. Epidemiological and laboratory findings suggest that post-infective immune dysregulation may play a predominant role. Further studies are crucial to elucidate the underlying pathogenesis. |
| first_indexed | 2024-03-10T09:53:36Z |
| format | Article |
| id | doaj.art-3b757df373494c96bf09a1c1547d5192 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:53:36Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3b757df373494c96bf09a1c1547d51922023-11-22T02:28:59ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011013295310.3390/jcm10132953Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19Tzu-Chen Lo0Yu-Yen Chen1Department of Medical Education, Taichung Veterans General Hospital, Taichung 407, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112, TaiwanThis study aimed to achieve a better understanding of the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease 2019 (COVID-19). We searched PubMed and Embase between December 2019 and March 2021 and included only peer-reviewed clinical studies or case series. The proportions of patients who had conjunctivitis, systemic symptoms/signs (s/s), Kawasaki disease (KD), and exposure history to suspected/confirmed COVID-19 cases were obtained. Moreover, positive rates of the nasopharyngeal real-time reverse transcriptase polymerase chain reaction (RT-PCR) and serum antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recorded. Overall, 32 studies with 1458 patients were included in the pooled analysis. Around half of the patients had conjunctivitis. The five most common systemic manifestations were fever (96.4%), gastrointestinal s/s (76.7%), shock (61.5%), rash (57.1%), and neurological s/s (36.8%). Almost one-third presented complete KD and about half had exposure history to COVID-19 cases. The positivity of the serology (82.2%) was higher than that of the nasopharyngeal RT-PCR (37.0%). MIS-C associated with COVID-19 leads to several features similar to KD. Epidemiological and laboratory findings suggest that post-infective immune dysregulation may play a predominant role. Further studies are crucial to elucidate the underlying pathogenesis.https://www.mdpi.com/2077-0383/10/13/2953multisystem inflammatory syndromeCOVID-19SARS-CoV-2meta-analysisconjunctivitis |
| spellingShingle | Tzu-Chen Lo Yu-Yen Chen Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 Journal of Clinical Medicine multisystem inflammatory syndrome COVID-19 SARS-CoV-2 meta-analysis conjunctivitis |
| title | Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 |
| title_full | Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 |
| title_fullStr | Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 |
| title_full_unstemmed | Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 |
| title_short | Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19 |
| title_sort | ocular and systemic manifestations in paediatric multisystem inflammatory syndrome associated with covid 19 |
| topic | multisystem inflammatory syndrome COVID-19 SARS-CoV-2 meta-analysis conjunctivitis |
| url | https://www.mdpi.com/2077-0383/10/13/2953 |
| work_keys_str_mv | AT tzuchenlo ocularandsystemicmanifestationsinpaediatricmultisysteminflammatorysyndromeassociatedwithcovid19 AT yuyenchen ocularandsystemicmanifestationsinpaediatricmultisysteminflammatorysyndromeassociatedwithcovid19 |