Targeting of cholera toxin A (ctxA) gene by zinc finger nuclease: pitfalls of using gene editing tools in prokaryotes

Targeting of cholera toxin A (ctxA) gene by zinc finger nuclease: pitfalls of using gene editing tools in prokaryotes

Background and purpose: The study was launched to use zinc finger nuclease (ZFN) technology to disrupt the cholera toxin gene (ctxA) for inhibiting CT toxin production in Vibrio cholera (V. cholera). Experimental approach: An engineered ZFN was designed to target the catalytic site of the ctxA gene....

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Bibliographic Details
Main Authors: Nafiseh Hosseini, Hossein Khanahmad, Bahram Nasr Esfahani, Mojgan Bandehpour, Laleh Shariati, Nushin Zahedi, Bahram Kazemi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
ctxa gene; gene editing tools; vibrio cholerae; zinc finger nuclease.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=2;spage=182;epage=190;aulast=Hosseini

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