Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.

Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.

PrPSc is formed from a normal glycosylphosphatidylinositol (GPI)-anchored prion protein (PrPC) by a posttranslational modification. Most GPI-anchored proteins have been shown to be cleaved by GPI phospholipases. Recently, GPI-phospholipase D (GPI-PLD) was shown to be a strictly specific enzyme for G...

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Bibliographic Details
Main Authors:	Jae-Kwang Jin, Byungki Jang, Hyoung Tae Jin, Eun-Kyoung Choi, Cha-Gyun Jung, Hiroyasu Akatsu, Jae-Il Kim, Richard I Carp, Yong-Sun Kim
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4395093?pdf=render

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