Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice
This study investigated the ability of Lactiplantibacillus plantarum SCS3 (L. plantarum SCS3) to alleviate oxidative stress in diabetic mice. Diabetic mouse model was established by administering 50 mg/kg (bodyweight) of streptozocin for 5 days. We then applied 0.5 mL of 1.0 × 1010 CFU/mL L. plantar...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | CyTA - Journal of Food |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2022.2136759 |
| _version_ | 1811329945906970624 |
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| author | Xiao Meng Shukun Liu Qiuyan Liu Ying Zhang Lin Jing Xinyi Huang Jiayi Sun Lu Ye |
| author_facet | Xiao Meng Shukun Liu Qiuyan Liu Ying Zhang Lin Jing Xinyi Huang Jiayi Sun Lu Ye |
| author_sort | Xiao Meng |
| collection | DOAJ |
| description | This study investigated the ability of Lactiplantibacillus plantarum SCS3 (L. plantarum SCS3) to alleviate oxidative stress in diabetic mice. Diabetic mouse model was established by administering 50 mg/kg (bodyweight) of streptozocin for 5 days. We then applied 0.5 mL of 1.0 × 1010 CFU/mL L. plantarum SCS3 cell suspension (TGa group), its intracellular contents (TGb group), or boiled intracellular contents (TGc group) to mice for ten weeks. Compared with the model group (MG), weight loss and hyperglycemia were most effectively ameliorated in the TGc group compared to the other treatment groups; based on the enzyme linked immunosorbent assay, levels of insulin and glycosylated hemoglobin were improved; the reactive oxygen species level decreased, while superoxide dismutase, catalase, and glutathione levels in the TGc mice increased significantly (P < .05). In conclusion, the boiled intracellular contents of L. plantarum SCS3 regulated oxidative stress and improved diabetes-related indicators in diabetic mice. |
| first_indexed | 2024-04-13T15:52:57Z |
| format | Article |
| id | doaj.art-3b780d6a495d4acdba119e340ecbc2c1 |
| institution | Directory Open Access Journal |
| issn | 1947-6337 1947-6345 |
| language | English |
| last_indexed | 2024-04-13T15:52:57Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj.art-3b780d6a495d4acdba119e340ecbc2c12022-12-22T02:40:47ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452022-12-0120129730410.1080/19476337.2022.2136759Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic miceXiao Meng0Shukun Liu1Qiuyan Liu2Ying Zhang3Lin Jing4Xinyi Huang5Jiayi Sun6Lu Ye7College of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaCollege of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaCollege of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaCollege of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaCollege of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaCollege of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaInnovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSecond Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, ChinaThis study investigated the ability of Lactiplantibacillus plantarum SCS3 (L. plantarum SCS3) to alleviate oxidative stress in diabetic mice. Diabetic mouse model was established by administering 50 mg/kg (bodyweight) of streptozocin for 5 days. We then applied 0.5 mL of 1.0 × 1010 CFU/mL L. plantarum SCS3 cell suspension (TGa group), its intracellular contents (TGb group), or boiled intracellular contents (TGc group) to mice for ten weeks. Compared with the model group (MG), weight loss and hyperglycemia were most effectively ameliorated in the TGc group compared to the other treatment groups; based on the enzyme linked immunosorbent assay, levels of insulin and glycosylated hemoglobin were improved; the reactive oxygen species level decreased, while superoxide dismutase, catalase, and glutathione levels in the TGc mice increased significantly (P < .05). In conclusion, the boiled intracellular contents of L. plantarum SCS3 regulated oxidative stress and improved diabetes-related indicators in diabetic mice.https://www.tandfonline.com/doi/10.1080/19476337.2022.2136759Lactiplantibacillus plantarum SCS3type 2 diabetesoxidative stressimprovementenzyme linked immunosorbent assayexperimental techniques |
| spellingShingle | Xiao Meng Shukun Liu Qiuyan Liu Ying Zhang Lin Jing Xinyi Huang Jiayi Sun Lu Ye Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice CyTA - Journal of Food Lactiplantibacillus plantarum SCS3 type 2 diabetes oxidative stress improvement enzyme linked immunosorbent assay experimental techniques |
| title | Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice |
| title_full | Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice |
| title_fullStr | Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice |
| title_full_unstemmed | Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice |
| title_short | Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice |
| title_sort | anti oxidative stress properties by lactiplantibacillus plantarum scs3 in streptozotocin induced diabetic mice |
| topic | Lactiplantibacillus plantarum SCS3 type 2 diabetes oxidative stress improvement enzyme linked immunosorbent assay experimental techniques |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2022.2136759 |
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