Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography
Introduction: Psoriasis (PsO), a chronic inflammatory, multisystemic, and multifactorial disease can cause endothelial dysfunction, artery calcification, and atherosclerotic disease. A higher incidence of vascular occlusive events has been observed in psoriatic patients compared to healthy controls,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mattioli1885
2022-02-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | http://www.dpcj.org/index.php/dpc/article/view/1745 |
| _version_ | 1831684503542693888 |
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| author | Annunziata Dattola Guglielmo Manenti Donatella Ferrari Laura Vollono Salvatore Marsico Feliciana Lamacchia Maria Esposito Mattia Marchesano Arianna Zangrilli Roberto Floris Alessandro Giunta Luca Bianchi |
| author_facet | Annunziata Dattola Guglielmo Manenti Donatella Ferrari Laura Vollono Salvatore Marsico Feliciana Lamacchia Maria Esposito Mattia Marchesano Arianna Zangrilli Roberto Floris Alessandro Giunta Luca Bianchi |
| author_sort | Annunziata Dattola |
| collection | DOAJ |
| description | Introduction: Psoriasis (PsO), a chronic inflammatory, multisystemic, and multifactorial disease can cause endothelial dysfunction, artery calcification, and atherosclerotic disease. A higher incidence of vascular occlusive events has been observed in psoriatic patients compared to healthy controls, and multiple studies confirm the association between moderate-severe PsO and atherosclerosis, coronary artery calcification, and higher cardiovascular risk.
Objective: We sought to analyze atherosclerotic disease prevalence in epiaortic vessels of psoriatic and non-psoriatic patients to understand if PsO could represent an independent risk factor predisposing to atherosclerotic disease.
Methods: We evaluated 47 psoriatic patients without cardiovascular risk factors with color Doppler ultrasound (CDUS). If atheromatous plaques were detected, a computed tomography angiography (CTA) was performed. We evaluated 47 non-psoriatic patients without cardiovascular risk factors with CDUS. Atherosclerosis prevalence in both groups were statistically analyzed. CDUS performance was compared to CTA.
Results: In the psoriatic group (mean age 50.9 years), 6 had atheromatous plaques and 12 had an intima-media thickness (IMT) > 1 mm (overall prevalence of atherosclerotic disease: 38.2%). All plaques detected with CDUS were confirmed at CTA. In the control group (mean age 51.3 years), CDUS revealed atheromatous plaques in 4 patients and IMT > 1 mm in 4 ones (overall prevalence of 17%). The difference of atherosclerotic disease prevalence between the groups was statistically significant (P < 0.05).
Conclusion: Our results highlight that PsO could be considered a predisposing factor for atherosclerotic disease development in epiaortic vessels, as it causes an increased IMT, that is also considered an independent cardiovascular risk factor. |
| first_indexed | 2024-12-20T08:03:08Z |
| format | Article |
| id | doaj.art-3b7813ea9da1424486b7608142df1448 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-12-20T08:03:08Z |
| publishDate | 2022-02-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-3b7813ea9da1424486b7608142df14482022-12-21T19:47:29ZengMattioli1885Dermatology Practical & Conceptual2160-93812022-02-0110.5826/dpc.1201a11Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography AngiographyAnnunziata Dattola0Guglielmo Manenti1Donatella Ferrari 2Laura Vollono 3Salvatore Marsico 4Feliciana Lamacchia5Maria Esposito 6Mattia Marchesano 7Arianna Zangrilli 8Roberto Floris 9Alessandro Giunta 10Luca Bianchi 11Dermatology Department, University of Rome “Tor Vergata”, Rome, ItalyBiomedicine and Prevention Department, UOC of Diagnostic Imaging, University of Rome “Tor Vergata”, Rome, ItalyBiomedicine and Prevention Department, UOC of Diagnostic Imaging, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyBiomedicine and Prevention Department, UOC of Diagnostic Imaging, University of Rome “Tor Vergata”, Rome, ItalyBiomedicine and Prevention Department, UOC of Diagnostic Imaging, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyBiomedicine and Prevention Department, UOC of Diagnostic Imaging, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyDermatology Department, University of Rome “Tor Vergata”, Rome, ItalyIntroduction: Psoriasis (PsO), a chronic inflammatory, multisystemic, and multifactorial disease can cause endothelial dysfunction, artery calcification, and atherosclerotic disease. A higher incidence of vascular occlusive events has been observed in psoriatic patients compared to healthy controls, and multiple studies confirm the association between moderate-severe PsO and atherosclerosis, coronary artery calcification, and higher cardiovascular risk. Objective: We sought to analyze atherosclerotic disease prevalence in epiaortic vessels of psoriatic and non-psoriatic patients to understand if PsO could represent an independent risk factor predisposing to atherosclerotic disease. Methods: We evaluated 47 psoriatic patients without cardiovascular risk factors with color Doppler ultrasound (CDUS). If atheromatous plaques were detected, a computed tomography angiography (CTA) was performed. We evaluated 47 non-psoriatic patients without cardiovascular risk factors with CDUS. Atherosclerosis prevalence in both groups were statistically analyzed. CDUS performance was compared to CTA. Results: In the psoriatic group (mean age 50.9 years), 6 had atheromatous plaques and 12 had an intima-media thickness (IMT) > 1 mm (overall prevalence of atherosclerotic disease: 38.2%). All plaques detected with CDUS were confirmed at CTA. In the control group (mean age 51.3 years), CDUS revealed atheromatous plaques in 4 patients and IMT > 1 mm in 4 ones (overall prevalence of 17%). The difference of atherosclerotic disease prevalence between the groups was statistically significant (P < 0.05). Conclusion: Our results highlight that PsO could be considered a predisposing factor for atherosclerotic disease development in epiaortic vessels, as it causes an increased IMT, that is also considered an independent cardiovascular risk factor.http://www.dpcj.org/index.php/dpc/article/view/1745psoriasis, color-Doppler Ultrasound, Angio-CT; IMT; risk-factor |
| spellingShingle | Annunziata Dattola Guglielmo Manenti Donatella Ferrari Laura Vollono Salvatore Marsico Feliciana Lamacchia Maria Esposito Mattia Marchesano Arianna Zangrilli Roberto Floris Alessandro Giunta Luca Bianchi Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography Dermatology Practical & Conceptual psoriasis, color-Doppler Ultrasound, Angio-CT; IMT; risk-factor |
| title | Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography |
| title_full | Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography |
| title_fullStr | Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography |
| title_full_unstemmed | Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography |
| title_short | Prevalence of Atherosclerosis in Psoriatic Patients Detected with Epiaortic Color Doppler Ultrasound and Computed Tomography Angiography |
| title_sort | prevalence of atherosclerosis in psoriatic patients detected with epiaortic color doppler ultrasound and computed tomography angiography |
| topic | psoriasis, color-Doppler Ultrasound, Angio-CT; IMT; risk-factor |
| url | http://www.dpcj.org/index.php/dpc/article/view/1745 |
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