Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment
Mild cognitive impairment (MCI) is becoming a serious problem for developing countries as the lifespan of populations increases. Exercise is known to be clinically beneficial for MCI patients. Somatosensory-evoked potentials (SEPs) may be a potential diagnostic and prognostic marker for this populat...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/10/663 |
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| author | Imran Amjad Imran Khan Niazi Hamza Ghazanfar Toor Rasmus Bach Nedergaard Muhammad Shafique Kelly Holt Heidi Haavik Touqeer Ahmed |
| author_facet | Imran Amjad Imran Khan Niazi Hamza Ghazanfar Toor Rasmus Bach Nedergaard Muhammad Shafique Kelly Holt Heidi Haavik Touqeer Ahmed |
| author_sort | Imran Amjad |
| collection | DOAJ |
| description | Mild cognitive impairment (MCI) is becoming a serious problem for developing countries as the lifespan of populations increases. Exercise is known to be clinically beneficial for MCI patients. Somatosensory-evoked potentials (SEPs) may be a potential diagnostic and prognostic marker for this population. The objective of this study was to determine the acute effects of aerobic exercise on SEPs in patients with MCI, to test whether SEPs are sensitive enough to detect improvements in early somatosensory processing. The study had a randomized parallel-group design and included 28 MCI subjects (14 in the experimental group and 14 in the control group). The experimental intervention was 20 min of aerobic exercise using a stationary bicycle. The control intervention involved 20 min of movements and stretches. Subjects were assessed before and after a single intervention session. SEPs were recorded by stimulating the median nerve of the dominant hand. Analysis of normalized SEP peak amplitudes showed that a single session of aerobic activity significantly reduced the N30 peak at the F3 channel (<i>p</i> = 0.03). There were no significant effects of aerobic exercise on SEP peak latencies. The results indicate that 20 min of aerobic exercise has a significant effect on the N30 SEP peak amplitude in MCI patients. The results suggest that aerobic exercise is likely to provide sensory-enriching inputs that enhance sensorimotor integration. Future studies should assess the effects of aerobic exercise on somatosensory processing in progressive stages of Alzheimer’s disease, longer exercise durations, and multiple exercise sessions. |
| first_indexed | 2024-03-10T16:06:27Z |
| format | Article |
| id | doaj.art-3b78c8bdc41c4ee9974a5ab3b5c6d98b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T16:06:27Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3b78c8bdc41c4ee9974a5ab3b5c6d98b2023-11-20T14:51:13ZengMDPI AGBrain Sciences2076-34252020-09-01101066310.3390/brainsci10100663Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive ImpairmentImran Amjad0Imran Khan Niazi1Hamza Ghazanfar Toor2Rasmus Bach Nedergaard3Muhammad Shafique4Kelly Holt5Heidi Haavik6Touqeer Ahmed7Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, PakistanCenter of Chiropractic Research New Zealand College of Chiropractic, Auckland 1060, New ZealandFaculty of Rehabilitation and Allied Sciences & Faculty of Engineering and Applied Sciences, Riphah International University, Islamabad 44000, PakistanMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, 9000 Aalborg, DenmarkFaculty of Rehabilitation and Allied Sciences & Faculty of Engineering and Applied Sciences, Riphah International University, Islamabad 44000, PakistanCenter of Chiropractic Research New Zealand College of Chiropractic, Auckland 1060, New ZealandCenter of Chiropractic Research New Zealand College of Chiropractic, Auckland 1060, New ZealandNeurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, PakistanMild cognitive impairment (MCI) is becoming a serious problem for developing countries as the lifespan of populations increases. Exercise is known to be clinically beneficial for MCI patients. Somatosensory-evoked potentials (SEPs) may be a potential diagnostic and prognostic marker for this population. The objective of this study was to determine the acute effects of aerobic exercise on SEPs in patients with MCI, to test whether SEPs are sensitive enough to detect improvements in early somatosensory processing. The study had a randomized parallel-group design and included 28 MCI subjects (14 in the experimental group and 14 in the control group). The experimental intervention was 20 min of aerobic exercise using a stationary bicycle. The control intervention involved 20 min of movements and stretches. Subjects were assessed before and after a single intervention session. SEPs were recorded by stimulating the median nerve of the dominant hand. Analysis of normalized SEP peak amplitudes showed that a single session of aerobic activity significantly reduced the N30 peak at the F3 channel (<i>p</i> = 0.03). There were no significant effects of aerobic exercise on SEP peak latencies. The results indicate that 20 min of aerobic exercise has a significant effect on the N30 SEP peak amplitude in MCI patients. The results suggest that aerobic exercise is likely to provide sensory-enriching inputs that enhance sensorimotor integration. Future studies should assess the effects of aerobic exercise on somatosensory processing in progressive stages of Alzheimer’s disease, longer exercise durations, and multiple exercise sessions.https://www.mdpi.com/2076-3425/10/10/663aerobic exerciseamplitudeEEGN30MCISEPs |
| spellingShingle | Imran Amjad Imran Khan Niazi Hamza Ghazanfar Toor Rasmus Bach Nedergaard Muhammad Shafique Kelly Holt Heidi Haavik Touqeer Ahmed Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment Brain Sciences aerobic exercise amplitude EEG N30 MCI SEPs |
| title | Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment |
| title_full | Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment |
| title_fullStr | Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment |
| title_full_unstemmed | Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment |
| title_short | Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment |
| title_sort | acute effects of aerobic exercise on somatosensory evoked potentials in patients with mild cognitive impairment |
| topic | aerobic exercise amplitude EEG N30 MCI SEPs |
| url | https://www.mdpi.com/2076-3425/10/10/663 |
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