Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation
Lymphocyte‐specific protein 1 (LSP1) has been reported to regulate cell biology in several human cancers including lymphoma and breast cancer. However, the functions of LSP1 in human hepatocellular carcinoma (HCC) are still unknown. In this study, we found that LSP1 expression was downregulated in H...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-12-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.12139 |
| _version_ | 1817971088505700352 |
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| author | Hongyong Zhang Yufeng Wang Zhikui Liu Bowen Yao Changwei Dou Meng Xu Qing Li Yuli Jia Shengli Wu Kangsheng Tu Qingguang Liu |
| author_facet | Hongyong Zhang Yufeng Wang Zhikui Liu Bowen Yao Changwei Dou Meng Xu Qing Li Yuli Jia Shengli Wu Kangsheng Tu Qingguang Liu |
| author_sort | Hongyong Zhang |
| collection | DOAJ |
| description | Lymphocyte‐specific protein 1 (LSP1) has been reported to regulate cell biology in several human cancers including lymphoma and breast cancer. However, the functions of LSP1 in human hepatocellular carcinoma (HCC) are still unknown. In this study, we found that LSP1 expression was downregulated in HCC tissues and cell lines, and lower LSP1 expression was correlated with poor clinicopathological features including large tumor size, high Edmondson–Steiner grading and advanced tumor–node–metastasis (TNM) stage. Additionally, we demonstrated that patients with high LSP1 expression had significantly better overall survival and disease‐free survival. Moreover, LSP1 was found to be an independent factor for predicting the prognosis of HCC patients. In vitro and in vivo assays showed that overexpressing LSP1 inhibited HCC growth by inducing both apoptosis and growth arrest. Mechanistically, we found that expression of phosphorylated extracellular regulated protein kinases 1 and 2 (ERK1/2) was downregulated after LSP1 overexpression, indicating LSP1 could suppress HCC growth by inhibiting the ERK pathway in HCC cells. Taken together, these results indicate that LSP1 may serve as a prognostic marker and a potential therapeutic target in human HCC. |
| first_indexed | 2024-04-13T20:43:23Z |
| format | Article |
| id | doaj.art-3b797fa9374e4999b226c7180dcf32bd |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-13T20:43:23Z |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-3b797fa9374e4999b226c7180dcf32bd2022-12-22T02:30:48ZengWileyFEBS Open Bio2211-54632016-12-016121227123710.1002/2211-5463.12139Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylationHongyong Zhang0Yufeng Wang1Zhikui Liu2Bowen Yao3Changwei Dou4Meng Xu5Qing Li6Yuli Jia7Shengli Wu8Kangsheng Tu9Qingguang Liu10Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaDepartment of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University ChinaLymphocyte‐specific protein 1 (LSP1) has been reported to regulate cell biology in several human cancers including lymphoma and breast cancer. However, the functions of LSP1 in human hepatocellular carcinoma (HCC) are still unknown. In this study, we found that LSP1 expression was downregulated in HCC tissues and cell lines, and lower LSP1 expression was correlated with poor clinicopathological features including large tumor size, high Edmondson–Steiner grading and advanced tumor–node–metastasis (TNM) stage. Additionally, we demonstrated that patients with high LSP1 expression had significantly better overall survival and disease‐free survival. Moreover, LSP1 was found to be an independent factor for predicting the prognosis of HCC patients. In vitro and in vivo assays showed that overexpressing LSP1 inhibited HCC growth by inducing both apoptosis and growth arrest. Mechanistically, we found that expression of phosphorylated extracellular regulated protein kinases 1 and 2 (ERK1/2) was downregulated after LSP1 overexpression, indicating LSP1 could suppress HCC growth by inhibiting the ERK pathway in HCC cells. Taken together, these results indicate that LSP1 may serve as a prognostic marker and a potential therapeutic target in human HCC.https://doi.org/10.1002/2211-5463.12139apoptosisextracellular regulated protein kinase pathwayhepatocellular carcinomalymphocyte‐specific protein 1proliferation |
| spellingShingle | Hongyong Zhang Yufeng Wang Zhikui Liu Bowen Yao Changwei Dou Meng Xu Qing Li Yuli Jia Shengli Wu Kangsheng Tu Qingguang Liu Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation FEBS Open Bio apoptosis extracellular regulated protein kinase pathway hepatocellular carcinoma lymphocyte‐specific protein 1 proliferation |
| title | Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation |
| title_full | Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation |
| title_fullStr | Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation |
| title_full_unstemmed | Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation |
| title_short | Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation |
| title_sort | retracted lymphocyte specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing erk1 2 phosphorylation |
| topic | apoptosis extracellular regulated protein kinase pathway hepatocellular carcinoma lymphocyte‐specific protein 1 proliferation |
| url | https://doi.org/10.1002/2211-5463.12139 |
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