Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece
Objective: To determine the prevalence of resistant strains of Staphylococcus aureus (S. aureus) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospit...
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MDPI AG
2017-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/6/4/39 |
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| author | Christina Stefanaki Alexandra Ieronymaki Theoni Matoula Chrysseis Caroni Evaggelia Polythodoraki Stella-Eugenia Chryssou George Kontochristopoulos Christina Antoniou |
| author_facet | Christina Stefanaki Alexandra Ieronymaki Theoni Matoula Chrysseis Caroni Evaggelia Polythodoraki Stella-Eugenia Chryssou George Kontochristopoulos Christina Antoniou |
| author_sort | Christina Stefanaki |
| collection | DOAJ |
| description | Objective: To determine the prevalence of resistant strains of Staphylococcus aureus (S. aureus) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospital with a skin infection between the years 2010–2015 were examined retrospectively. Bacterial cultures, identification of S. aureus and antimicrobial susceptibility testing were performed using the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines and European Committee on Antimicrobial testing (EUCAST) breakpoints. EUCAST breakpoints were applied if no CLSI were available. Results: Of 2069 S. aureus isolates identified, 1845 (88%) were resistant to one or more antibiotics. The highest resistance was observed for benzylpenicillin (71.9%), followed by erythromycin (34.3%). Resistant strains to cefoxitin defined as MRSA (methicillin-resistant S. aureus) represented 21% of total isolates. Interestingly, resistance to fusidic acid was 22.9% and to mupirocin as high as 12.7%. Low rates were observed for minocycline, rifampicin and trimethoprim/sulfamethoxazole (SXT). Resistance to antibiotics remained relatively stable throughout the six-year period, with the exception of cefoxitin, fusidic acid and SXT. A high percentage of MRSA strains were resistant to erythromycin (60%), fusidic acid (46%), clindamycin (38%) and tetracycline (35.5%). Conclusions: Special attention is required in prescribing appropriate antibiotic therapeutic regimens, particularly for MRSA. These data on the susceptibility of S. aureus may be useful for guiding antibiotic treatment. |
| first_indexed | 2024-12-11T18:11:32Z |
| format | Article |
| id | doaj.art-3b7aed32e1824d609fc41e793cb24397 |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-11T18:11:32Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-3b7aed32e1824d609fc41e793cb243972022-12-22T00:55:34ZengMDPI AGAntibiotics2079-63822017-12-01643910.3390/antibiotics6040039antibiotics6040039Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in GreeceChristina Stefanaki0Alexandra Ieronymaki1Theoni Matoula2Chrysseis Caroni3Evaggelia Polythodoraki4Stella-Eugenia Chryssou5George Kontochristopoulos6Christina Antoniou7Dermatology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceMicrobiology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceDermatology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceDepartment of Statistics and Mathematics, National Technical University of Athens, 15780 Athens, GreeceMicrobiology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceMicrobiology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceDermatology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceDermatology Department, Andreas Sygros University Skin Hospital, 16121 Athens, GreeceObjective: To determine the prevalence of resistant strains of Staphylococcus aureus (S. aureus) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospital with a skin infection between the years 2010–2015 were examined retrospectively. Bacterial cultures, identification of S. aureus and antimicrobial susceptibility testing were performed using the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines and European Committee on Antimicrobial testing (EUCAST) breakpoints. EUCAST breakpoints were applied if no CLSI were available. Results: Of 2069 S. aureus isolates identified, 1845 (88%) were resistant to one or more antibiotics. The highest resistance was observed for benzylpenicillin (71.9%), followed by erythromycin (34.3%). Resistant strains to cefoxitin defined as MRSA (methicillin-resistant S. aureus) represented 21% of total isolates. Interestingly, resistance to fusidic acid was 22.9% and to mupirocin as high as 12.7%. Low rates were observed for minocycline, rifampicin and trimethoprim/sulfamethoxazole (SXT). Resistance to antibiotics remained relatively stable throughout the six-year period, with the exception of cefoxitin, fusidic acid and SXT. A high percentage of MRSA strains were resistant to erythromycin (60%), fusidic acid (46%), clindamycin (38%) and tetracycline (35.5%). Conclusions: Special attention is required in prescribing appropriate antibiotic therapeutic regimens, particularly for MRSA. These data on the susceptibility of S. aureus may be useful for guiding antibiotic treatment.https://www.mdpi.com/2079-6382/6/4/39Staphylococcus aureusMRSAcefoxitinmupirocinfusidic acidresistance |
| spellingShingle | Christina Stefanaki Alexandra Ieronymaki Theoni Matoula Chrysseis Caroni Evaggelia Polythodoraki Stella-Eugenia Chryssou George Kontochristopoulos Christina Antoniou Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece Antibiotics Staphylococcus aureus MRSA cefoxitin mupirocin fusidic acid resistance |
| title | Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece |
| title_full | Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece |
| title_fullStr | Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece |
| title_full_unstemmed | Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece |
| title_short | Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece |
| title_sort | six year retrospective review of hospital data on antimicrobial resistance profile of staphylococcus aureus isolated from skin infections from a single institution in greece |
| topic | Staphylococcus aureus MRSA cefoxitin mupirocin fusidic acid resistance |
| url | https://www.mdpi.com/2079-6382/6/4/39 |
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