Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice
Introduction: Recent studies suggest that glucocorticoids modulate memory reconsolidation. Moreover, cholinergic system is involved in memory reconsolidation. Since glucocorticoids interact with brain cholinergic system in modulating memory processing, we investigated whether glucocorticoid influenc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2015-07-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1 |
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| author | Somayeh Amiri Zahra Jafarian Abbas Ali Vafaei Ali Rashidy-Pour Zahra Motaghed larijani Seyed Afshin Samaei |
| author_facet | Somayeh Amiri Zahra Jafarian Abbas Ali Vafaei Ali Rashidy-Pour Zahra Motaghed larijani Seyed Afshin Samaei |
| author_sort | Somayeh Amiri |
| collection | DOAJ |
| description | Introduction: Recent studies suggest that glucocorticoids modulate memory reconsolidation.
Moreover, cholinergic system is involved in memory reconsolidation. Since glucocorticoids
interact with brain cholinergic system in modulating memory processing, we investigated
whether glucocorticoid influences on the reconsolidation of emotionally arousing training
depend on the cholinergic system. Methods: Mice were trained (1mA, 3s footshock) in an inhibitory avoidance task. Forty-eight
hours after training, memory reactivation was occurred (Test 1), and different treatments were
given. Two (Test 2), five (Test 3), and seven days (Test 4) after memory reactivation (Test 1),
animals were retested for fear memory retention. Results: In the first experiment, we observed that administration of corticosterone (CORT, 0.3,
1 and 3 mg/kg) following memory reactivation impaired subsequent expression of memory in a
dose-dependent manner. In the second experiment, we found that CORT-induced impairment of
memory reconsolidation was reversed by the muscarinic receptor antagonist atropine (0.5 and 2
mg/kg). In the third experiment, the nicotinic receptor antagonist mecaylamine (0.5 or 2 mg/kg)
was not able to block the corticosterone response. Discussion: These findings indicate that glucocorticoids impair memory reconsolidation by a
muscarinic cholinergic mechanism. |
| first_indexed | 2024-03-07T17:55:39Z |
| format | Article |
| id | doaj.art-3b7b7700f8ac4545bb71bb4668272fee |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:55:39Z |
| publishDate | 2015-07-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-3b7b7700f8ac4545bb71bb4668272fee2024-03-02T12:14:08ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422015-07-0163155162Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in MiceSomayeh Amiri0Zahra Jafarian1Abbas Ali Vafaei2Ali Rashidy-Pour3Zahra Motaghed larijani4Seyed Afshin Samaei5 Laboratory of Learning and Memory, Department and Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran. Laboratory of Learning and Memory, Department and Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran. Laboratory of Learning and Memory, Department and Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran. Semnan University of Medical Sciences Introduction: Recent studies suggest that glucocorticoids modulate memory reconsolidation. Moreover, cholinergic system is involved in memory reconsolidation. Since glucocorticoids interact with brain cholinergic system in modulating memory processing, we investigated whether glucocorticoid influences on the reconsolidation of emotionally arousing training depend on the cholinergic system. Methods: Mice were trained (1mA, 3s footshock) in an inhibitory avoidance task. Forty-eight hours after training, memory reactivation was occurred (Test 1), and different treatments were given. Two (Test 2), five (Test 3), and seven days (Test 4) after memory reactivation (Test 1), animals were retested for fear memory retention. Results: In the first experiment, we observed that administration of corticosterone (CORT, 0.3, 1 and 3 mg/kg) following memory reactivation impaired subsequent expression of memory in a dose-dependent manner. In the second experiment, we found that CORT-induced impairment of memory reconsolidation was reversed by the muscarinic receptor antagonist atropine (0.5 and 2 mg/kg). In the third experiment, the nicotinic receptor antagonist mecaylamine (0.5 or 2 mg/kg) was not able to block the corticosterone response. Discussion: These findings indicate that glucocorticoids impair memory reconsolidation by a muscarinic cholinergic mechanism.http://bcn.iums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1Memory reconsolidation Glucocorticoids Cholinergic agents |
| spellingShingle | Somayeh Amiri Zahra Jafarian Abbas Ali Vafaei Ali Rashidy-Pour Zahra Motaghed larijani Seyed Afshin Samaei Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice Basic and Clinical Neuroscience Memory reconsolidation Glucocorticoids Cholinergic agents |
| title | Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice |
| title_full | Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice |
| title_fullStr | Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice |
| title_full_unstemmed | Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice |
| title_short | Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice |
| title_sort | glucocorticoids interact with cholinergic system in impairing memory reconsolidation of an inhibitory avoidance task in mice |
| topic | Memory reconsolidation Glucocorticoids Cholinergic agents |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1 |
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