Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh
<b>Background and Aims:</b> Blood donation from glucose-6-phosphate dehydrogenase (G6PD)-deficient and sickle cell trait (SCT) donors might alter the quality of the donated blood during processing, storage or in the recipient′s circulatory system. The aim of this study was to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2010;volume=4;issue=1;spage=31;epage=33;aulast=Alabdulaali |
| _version_ | 1811255459844194304 |
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| author | Alabdulaali Mohammed Alayed Khaled Alshaikh Abdulaziz Almashhadani Shihab |
| author_facet | Alabdulaali Mohammed Alayed Khaled Alshaikh Abdulaziz Almashhadani Shihab |
| author_sort | Alabdulaali Mohammed |
| collection | DOAJ |
| description | <b>Background and Aims:</b> Blood donation from glucose-6-phosphate dehydrogenase (G6PD)-deficient and sickle cell trait (SCT) donors might alter the quality of the donated blood during processing, storage or in the recipient′s circulatory system. The aim of this study was to determine the prevalence of G6PD deficiency and SCT among blood donors coming to King Khalid University Hospital (KKUH) in Riyadh. It was also reviewed the benefits and risks of transfusing blood from these blood donors. <b> Materials and Methods:</b> This cross-sectional study was conducted on 1150 blood samples obtained from blood donors that presented to KKUH blood bank during the period April 2006 to May 2006. All samples were tested for Hb-S by solubility test, alkaline gel electrophoresis; and for G6PD deficiency, by fluorescent spot test. <b> Results:</b> Out of the 1150 donors, 23 (2%) were diagnosed for SCT, 9 (0.78%) for G6PD deficiency and 4 (0.35%) for both conditions. Our prevalence of SCT and G6PD deficiency is higher than that of the general population of Riyadh. <b> Conclusion:</b> We recommend to screen all units for G6PD deficiency and sickle cell trait and to defer donations from donors with either of these conditions, unless if needed for special blood group compatibility, platelet apheresis or if these are likely to affect the blood bank inventory. If such blood is to be used, special precautions need to be undertaken to avoid complications in high-risk recipients. |
| first_indexed | 2024-04-12T17:25:11Z |
| format | Article |
| id | doaj.art-3b7b784259d44926a05d8d9c0c8e43d4 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-12T17:25:11Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-3b7b784259d44926a05d8d9c0c8e43d42022-12-22T03:23:20ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652010-01-01413133Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in RiyadhAlabdulaali MohammedAlayed KhaledAlshaikh AbdulazizAlmashhadani Shihab<b>Background and Aims:</b> Blood donation from glucose-6-phosphate dehydrogenase (G6PD)-deficient and sickle cell trait (SCT) donors might alter the quality of the donated blood during processing, storage or in the recipient′s circulatory system. The aim of this study was to determine the prevalence of G6PD deficiency and SCT among blood donors coming to King Khalid University Hospital (KKUH) in Riyadh. It was also reviewed the benefits and risks of transfusing blood from these blood donors. <b> Materials and Methods:</b> This cross-sectional study was conducted on 1150 blood samples obtained from blood donors that presented to KKUH blood bank during the period April 2006 to May 2006. All samples were tested for Hb-S by solubility test, alkaline gel electrophoresis; and for G6PD deficiency, by fluorescent spot test. <b> Results:</b> Out of the 1150 donors, 23 (2%) were diagnosed for SCT, 9 (0.78%) for G6PD deficiency and 4 (0.35%) for both conditions. Our prevalence of SCT and G6PD deficiency is higher than that of the general population of Riyadh. <b> Conclusion:</b> We recommend to screen all units for G6PD deficiency and sickle cell trait and to defer donations from donors with either of these conditions, unless if needed for special blood group compatibility, platelet apheresis or if these are likely to affect the blood bank inventory. If such blood is to be used, special precautions need to be undertaken to avoid complications in high-risk recipients.http://www.ajts.org/article.asp?issn=0973-6247;year=2010;volume=4;issue=1;spage=31;epage=33;aulast=AlabdulaaliBlood transfusionglucose-6-phosphate dehydrogenase deficiencysickle cell trait |
| spellingShingle | Alabdulaali Mohammed Alayed Khaled Alshaikh Abdulaziz Almashhadani Shihab Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh Asian Journal of Transfusion Science Blood transfusion glucose-6-phosphate dehydrogenase deficiency sickle cell trait |
| title | Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh |
| title_full | Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh |
| title_fullStr | Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh |
| title_full_unstemmed | Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh |
| title_short | Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh |
| title_sort | prevalence of glucose 6 phosphate dehydrogenase deficiency and sickle cell trait among blood donors in riyadh |
| topic | Blood transfusion glucose-6-phosphate dehydrogenase deficiency sickle cell trait |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2010;volume=4;issue=1;spage=31;epage=33;aulast=Alabdulaali |
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