Comparison of plateletpheresis on three continuous flow cell separators
<b>Introduction:</b> Platelet concentrate (PC) remains one of the most important support measures in thrombocytopenic patients. An efficient cell separator is a prerequisite for an optimally functioning apheresis setup. Donor blood count may undergo a temporary reduction after the proce...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=73;epage=77;aulast=Tendulkar |
| _version_ | 1818506395775926272 |
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| author | Tendulkar Anita Rajadhyaksha Sunil |
| author_facet | Tendulkar Anita Rajadhyaksha Sunil |
| author_sort | Tendulkar Anita |
| collection | DOAJ |
| description | <b>Introduction:</b> Platelet concentrate (PC) remains one of the most important support measures in thrombocytopenic patients. An efficient cell separator is a prerequisite for an optimally functioning apheresis setup. Donor blood count may undergo a temporary reduction after the procedure. <b> Aim:</b> The aim was to find the extent of reduction in donor blood count (hemoglobin, hematocrit, white blood cell, and platelet) after plateletpheresis and to evaluate the cell separator for collection efficiency, processing time, and leukoreduction. <b> Study Design and Methods:</b> Two hundred and thirty seven procedures performed on the Amicus (N = 121), Fenwal CS-3000 Plus (N = 50) and Cobe spectra (N = 66) in a one year period were evaluated. The procedures performed on the continuous flow centrifugation (CFC) cell separators and donor blood counts (pre and post donation) done were included in the study. <b> Results:</b> The percent reduction in hemoglobin (HB), hematocrit (HCT), white blood cell (WBC) and platelet count ((PLT ct) was 2.9, 3.1, 9, 30.7 (Mean, N = 237) respectively after the procedure. The post donation PLT ct reduced to < 100x109/L (range 80-100) in five donors (N = 5/237, Amicus). The pre donation PLT ct in them was 150-200x109/L. Collection efficiency (percent) of Amicus (79.3) was better as compared to the other two machines (CS: 62.5, Cobe: 57.5). PC collected on Cobe spectra had < 1x106 WBC. The donor pre donation PLT levels had a positive correlation to the product PLT yield (r = 0.30, <i> P</i> = 0.000). <b> Conclusion:</b> Monitoring donor blood counts helps to avoid pheresis induced adverse events. A cautious approach is necessary in donors whose pre donation PLT ct is 150-200x109/L. The main variable in PLT yield is donor PLT ct (pre donation). High collection efficiency is a direct measure of an optimally functioning cell separator. |
| first_indexed | 2024-12-10T22:03:59Z |
| format | Article |
| id | doaj.art-3b7bd7d598ab4523ba1ef26f44d76a89 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-10T22:03:59Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-3b7bd7d598ab4523ba1ef26f44d76a892022-12-22T01:31:49ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652009-01-01327377Comparison of plateletpheresis on three continuous flow cell separatorsTendulkar AnitaRajadhyaksha Sunil<b>Introduction:</b> Platelet concentrate (PC) remains one of the most important support measures in thrombocytopenic patients. An efficient cell separator is a prerequisite for an optimally functioning apheresis setup. Donor blood count may undergo a temporary reduction after the procedure. <b> Aim:</b> The aim was to find the extent of reduction in donor blood count (hemoglobin, hematocrit, white blood cell, and platelet) after plateletpheresis and to evaluate the cell separator for collection efficiency, processing time, and leukoreduction. <b> Study Design and Methods:</b> Two hundred and thirty seven procedures performed on the Amicus (N = 121), Fenwal CS-3000 Plus (N = 50) and Cobe spectra (N = 66) in a one year period were evaluated. The procedures performed on the continuous flow centrifugation (CFC) cell separators and donor blood counts (pre and post donation) done were included in the study. <b> Results:</b> The percent reduction in hemoglobin (HB), hematocrit (HCT), white blood cell (WBC) and platelet count ((PLT ct) was 2.9, 3.1, 9, 30.7 (Mean, N = 237) respectively after the procedure. The post donation PLT ct reduced to < 100x109/L (range 80-100) in five donors (N = 5/237, Amicus). The pre donation PLT ct in them was 150-200x109/L. Collection efficiency (percent) of Amicus (79.3) was better as compared to the other two machines (CS: 62.5, Cobe: 57.5). PC collected on Cobe spectra had < 1x106 WBC. The donor pre donation PLT levels had a positive correlation to the product PLT yield (r = 0.30, <i> P</i> = 0.000). <b> Conclusion:</b> Monitoring donor blood counts helps to avoid pheresis induced adverse events. A cautious approach is necessary in donors whose pre donation PLT ct is 150-200x109/L. The main variable in PLT yield is donor PLT ct (pre donation). High collection efficiency is a direct measure of an optimally functioning cell separator.http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=73;epage=77;aulast=TendulkarContinuous flow cell separatordonor blood countplateletpheresisplatelet yieldBlood donorapheresis |
| spellingShingle | Tendulkar Anita Rajadhyaksha Sunil Comparison of plateletpheresis on three continuous flow cell separators Asian Journal of Transfusion Science Continuous flow cell separator donor blood count plateletpheresis platelet yield Blood donor apheresis |
| title | Comparison of plateletpheresis on three continuous flow cell separators |
| title_full | Comparison of plateletpheresis on three continuous flow cell separators |
| title_fullStr | Comparison of plateletpheresis on three continuous flow cell separators |
| title_full_unstemmed | Comparison of plateletpheresis on three continuous flow cell separators |
| title_short | Comparison of plateletpheresis on three continuous flow cell separators |
| title_sort | comparison of plateletpheresis on three continuous flow cell separators |
| topic | Continuous flow cell separator donor blood count plateletpheresis platelet yield Blood donor apheresis |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=73;epage=77;aulast=Tendulkar |
| work_keys_str_mv | AT tendulkaranita comparisonofplateletpheresisonthreecontinuousflowcellseparators AT rajadhyakshasunil comparisonofplateletpheresisonthreecontinuousflowcellseparators |