Usefulness of PET With [18F]LBT-999 for the Evaluation of Presynaptic Dopaminergic Neuronal Loss in a Clinical Environment

Usefulness of PET With [18F]LBT-999 for the Evaluation of Presynaptic Dopaminergic Neuronal Loss in a Clinical Environment

Purpose: The density of the neuronal dopamine transporter (DAT) is directly correlated with the presynaptic dopaminergic system injury. In a first study, we evaluated the brain distribution and kinetics of [18F]LBT-999, a DAT PET radioligand, in a group of eight healthy subjects. Taking into account...

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Main Authors: Maria-Joao Ribeiro, Johnny Vercouillie, Nicolas Arlicot, Clovis Tauber, Valérie Gissot, Karl Mondon, Laurent Barantin, Jean-Philippe Cottier, Serge Maia, Jean-Bernard Deloye, Patrick Emond, Denis Guilloteau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
dopamine
DAT
PET
radiopharmaceutical
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00754/full

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