NFATc1 controls the cytotoxicity of CD8+ T cells
NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00612-6 |
| _version_ | 1818855844287086592 |
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| author | Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling |
| author_facet | Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling |
| author_sort | Stefan Klein-Hessling |
| collection | DOAJ |
| description | NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells. |
| first_indexed | 2024-12-19T08:15:03Z |
| format | Article |
| id | doaj.art-3b7e704afb8e41c391e25990abf690c1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:15:03Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b7e704afb8e41c391e25990abf690c12022-12-21T20:29:31ZengNature PortfolioNature Communications2041-17232017-09-018111510.1038/s41467-017-00612-6NFATc1 controls the cytotoxicity of CD8+ T cellsStefan Klein-Hessling0Khalid Muhammad1Matthias Klein2Tobias Pusch3Ronald Rudolf4Jessica Flöter5Musga Qureischi6Andreas Beilhack7Martin Vaeth8Carsten Kummerow9Christian Backes10Rouven Schoppmeyer11Ulrike Hahn12Markus Hoth13Tobias Bopp14Friederike Berberich-Siebelt15Amiya Patra16Andris Avots17Nora Müller18Almut Schulze19Edgar Serfling20Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgInstitute for Immunology, University Medical Center, University of MainzDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University WürzburgDepartment of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland UniversityDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland UniversityDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland UniversityCellular Neurophysiology, CIPMM, Saarland UniversityDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland UniversityInstitute for Immunology, University Medical Center, University of MainzDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgInstitute for Virology and Immunobiology, University of WürzburgDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of WürzburgDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of WürzburgNFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.https://doi.org/10.1038/s41467-017-00612-6 |
| spellingShingle | Stefan Klein-Hessling Khalid Muhammad Matthias Klein Tobias Pusch Ronald Rudolf Jessica Flöter Musga Qureischi Andreas Beilhack Martin Vaeth Carsten Kummerow Christian Backes Rouven Schoppmeyer Ulrike Hahn Markus Hoth Tobias Bopp Friederike Berberich-Siebelt Amiya Patra Andris Avots Nora Müller Almut Schulze Edgar Serfling NFATc1 controls the cytotoxicity of CD8+ T cells Nature Communications |
| title | NFATc1 controls the cytotoxicity of CD8+ T cells |
| title_full | NFATc1 controls the cytotoxicity of CD8+ T cells |
| title_fullStr | NFATc1 controls the cytotoxicity of CD8+ T cells |
| title_full_unstemmed | NFATc1 controls the cytotoxicity of CD8+ T cells |
| title_short | NFATc1 controls the cytotoxicity of CD8+ T cells |
| title_sort | nfatc1 controls the cytotoxicity of cd8 t cells |
| url | https://doi.org/10.1038/s41467-017-00612-6 |
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