The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer

The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer

Abstract Background Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet the molecular basis underlying CRC chemoresistance remains poorly understood, impeding the development of new therapeutic interventions. Elongation factor Tu GTP binding domain contai...

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Bibliographic Details
Main Authors: Xiaojian Zhu, Changxue Li, Yunfei Gao, Qingyuan Zhang, Tao Wang, Huaixiang Zhou, Fanqin Bu, Jia Chen, Xinjun Mao, Yulong He, Kaiming Wu, Ningning Li, Hongliang Luo
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
c-MYC
Chemotherapy sensitivity
EFTUD2
Prognostic indicator
Ubiquitylation
Online Access:https://doi.org/10.1186/s13046-023-02873-0

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