Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence
<i>Aspergillus fumigatus</i> is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has been associated with its virul...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/7/518 |
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| author | Uxue Perez-Cuesta Xabier Guruceaga Saioa Cendon-Sanchez Eduardo Pelegri-Martinez Fernando L. Hernando Andoni Ramirez-Garcia Ana Abad-Diaz-de-Cerio Aitor Rementeria |
| author_facet | Uxue Perez-Cuesta Xabier Guruceaga Saioa Cendon-Sanchez Eduardo Pelegri-Martinez Fernando L. Hernando Andoni Ramirez-Garcia Ana Abad-Diaz-de-Cerio Aitor Rementeria |
| author_sort | Uxue Perez-Cuesta |
| collection | DOAJ |
| description | <i>Aspergillus fumigatus</i> is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has been associated with its virulence. Of these, nitrogen, iron, and zinc metabolism-related genes are particularly noteworthy, since 78% of them have a direct implication in virulence. In this review, we describe the sensing, uptake and regulation process of the acquisition of these nutrients, the connections between pathways and the virulence-implicated genes. Nevertheless, only 40% of the genes mentioned in this review have been assayed for roles in virulence, leaving a wide field of knowledge that remains uncertain and might offer new therapeutic and diagnostic targets. |
| first_indexed | 2024-03-10T09:59:30Z |
| format | Article |
| id | doaj.art-3b804d1385264595ad8b1895ec602abf |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T09:59:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-3b804d1385264595ad8b1895ec602abf2023-11-22T02:02:02ZengMDPI AGJournal of Fungi2309-608X2021-06-017751810.3390/jof7070518Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> VirulenceUxue Perez-Cuesta0Xabier Guruceaga1Saioa Cendon-Sanchez2Eduardo Pelegri-Martinez3Fernando L. Hernando4Andoni Ramirez-Garcia5Ana Abad-Diaz-de-Cerio6Aitor Rementeria7Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainFungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain<i>Aspergillus fumigatus</i> is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has been associated with its virulence. Of these, nitrogen, iron, and zinc metabolism-related genes are particularly noteworthy, since 78% of them have a direct implication in virulence. In this review, we describe the sensing, uptake and regulation process of the acquisition of these nutrients, the connections between pathways and the virulence-implicated genes. Nevertheless, only 40% of the genes mentioned in this review have been assayed for roles in virulence, leaving a wide field of knowledge that remains uncertain and might offer new therapeutic and diagnostic targets.https://www.mdpi.com/2309-608X/7/7/518<i>Aspergillus fumigatus</i>nitrogenironzincnutrient acquisitionsiderophores |
| spellingShingle | Uxue Perez-Cuesta Xabier Guruceaga Saioa Cendon-Sanchez Eduardo Pelegri-Martinez Fernando L. Hernando Andoni Ramirez-Garcia Ana Abad-Diaz-de-Cerio Aitor Rementeria Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence Journal of Fungi <i>Aspergillus fumigatus</i> nitrogen iron zinc nutrient acquisition siderophores |
| title | Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence |
| title_full | Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence |
| title_fullStr | Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence |
| title_full_unstemmed | Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence |
| title_short | Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to <i>Aspergillus fumigatus</i> Virulence |
| title_sort | nitrogen iron and zinc acquisition key nutrients to i aspergillus fumigatus i virulence |
| topic | <i>Aspergillus fumigatus</i> nitrogen iron zinc nutrient acquisition siderophores |
| url | https://www.mdpi.com/2309-608X/7/7/518 |
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