NK Cell-Based Immunotherapy in Colorectal Cancer
Human Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed cells and the ability to modulate the subsequent adaptive immune response. The potential of immunotherapies based on NK cell involvement has been initially revealed i...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/7/1033 |
| _version_ | 1797415166873174016 |
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| author | Mariella Della Chiesa Chiara Setti Chiara Giordano Valentina Obino Marco Greppi Silvia Pesce Emanuela Marcenaro Mariangela Rutigliani Nicoletta Provinciali Laura Paleari Andrea DeCensi Simona Sivori Simona Carlomagno |
| author_facet | Mariella Della Chiesa Chiara Setti Chiara Giordano Valentina Obino Marco Greppi Silvia Pesce Emanuela Marcenaro Mariangela Rutigliani Nicoletta Provinciali Laura Paleari Andrea DeCensi Simona Sivori Simona Carlomagno |
| author_sort | Mariella Della Chiesa |
| collection | DOAJ |
| description | Human Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed cells and the ability to modulate the subsequent adaptive immune response. The potential of immunotherapies based on NK cell involvement has been initially revealed in the hematological setting but has inspired the design of different immune tools to also be applied against solid tumors, including colorectal cancer (CRC). Indeed, despite cancer prevention screening plans, surgery, and chemotherapy strategies, CRC is one of the most widespread cancers and with the highest mortality rate. Therefore, further efficient and complementary immune-based therapies are in urgent need. In this review, we gathered the most recent advances in NK cell-based immunotherapies aimed at fighting CRC, in particular, the use of monoclonal antibodies targeting tumor-associated antigens (TAAs), immune checkpoint blockade, and adoptive NK cell therapy, including NK cells modified with chimeric antigen receptor (CAR-NK). |
| first_indexed | 2024-03-09T05:43:57Z |
| format | Article |
| id | doaj.art-3b8165208dec4d8e81527873a4f75925 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T05:43:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3b8165208dec4d8e81527873a4f759252023-12-03T12:22:14ZengMDPI AGVaccines2076-393X2022-06-01107103310.3390/vaccines10071033NK Cell-Based Immunotherapy in Colorectal CancerMariella Della Chiesa0Chiara Setti1Chiara Giordano2Valentina Obino3Marco Greppi4Silvia Pesce5Emanuela Marcenaro6Mariangela Rutigliani7Nicoletta Provinciali8Laura Paleari9Andrea DeCensi10Simona Sivori11Simona Carlomagno12Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyPathology Unit, Galliera Hospital, 16128 Genoa, ItalyMedical Oncology, Galliera Hospital, 16128 Genoa, ItalyA.Li.Sa., Liguria Region Health Authority, 16121 Genoa, ItalyMedical Oncology, Galliera Hospital, 16128 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, ItalyHuman Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed cells and the ability to modulate the subsequent adaptive immune response. The potential of immunotherapies based on NK cell involvement has been initially revealed in the hematological setting but has inspired the design of different immune tools to also be applied against solid tumors, including colorectal cancer (CRC). Indeed, despite cancer prevention screening plans, surgery, and chemotherapy strategies, CRC is one of the most widespread cancers and with the highest mortality rate. Therefore, further efficient and complementary immune-based therapies are in urgent need. In this review, we gathered the most recent advances in NK cell-based immunotherapies aimed at fighting CRC, in particular, the use of monoclonal antibodies targeting tumor-associated antigens (TAAs), immune checkpoint blockade, and adoptive NK cell therapy, including NK cells modified with chimeric antigen receptor (CAR-NK).https://www.mdpi.com/2076-393X/10/7/1033NK cellsmonoclonal antibodiesbispecific antibodiestrispecific engagersimmune checkpointsCAR-NK cells |
| spellingShingle | Mariella Della Chiesa Chiara Setti Chiara Giordano Valentina Obino Marco Greppi Silvia Pesce Emanuela Marcenaro Mariangela Rutigliani Nicoletta Provinciali Laura Paleari Andrea DeCensi Simona Sivori Simona Carlomagno NK Cell-Based Immunotherapy in Colorectal Cancer Vaccines NK cells monoclonal antibodies bispecific antibodies trispecific engagers immune checkpoints CAR-NK cells |
| title | NK Cell-Based Immunotherapy in Colorectal Cancer |
| title_full | NK Cell-Based Immunotherapy in Colorectal Cancer |
| title_fullStr | NK Cell-Based Immunotherapy in Colorectal Cancer |
| title_full_unstemmed | NK Cell-Based Immunotherapy in Colorectal Cancer |
| title_short | NK Cell-Based Immunotherapy in Colorectal Cancer |
| title_sort | nk cell based immunotherapy in colorectal cancer |
| topic | NK cells monoclonal antibodies bispecific antibodies trispecific engagers immune checkpoints CAR-NK cells |
| url | https://www.mdpi.com/2076-393X/10/7/1033 |
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