Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis
Objective The objective of this study was to compare intra-articular injections (IAIs) of platelet-rich plasma (PRP) and corticosteroid injections in reducing pain and studying which has a more effective and lasting functional improvement. Patients and methods A total of 60 patients with chronic kne...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
General Organization of Teaching Hospitals and Institutes
2018-01-01
|
| Series: | Journal of Medicine in Scientific Research |
| Subjects: | |
| Online Access: | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=4;spage=278;epage=284;aulast=Ismaiel |
| _version_ | 1797227084935856128 |
|---|---|
| author | Abeer H Ismaiel |
| author_facet | Abeer H Ismaiel |
| author_sort | Abeer H Ismaiel |
| collection | DOAJ |
| description | Objective
The objective of this study was to compare intra-articular injections (IAIs) of platelet-rich plasma (PRP) and corticosteroid injections in reducing pain and studying which has a more effective and lasting functional improvement.
Patients and methods
A total of 60 patients with chronic knee osteoarthritis (Kellgren–Lawrence grades 3 and 4) were enrolled in this study. Patients were randomized to treatment either with a single leukocyte-rich PRP or corticosteroid IAIs. Patients were assessed by visual analog scale, and Knee injury and Osteoarthritis Outcome Score at 1, 3, and 6 months after treatment.
Results
Our results showed improvement in all variables in both groups. Statistical differences between groups were found for the majority of the outcome variables, and the degree of improvement was more in the PRP group.
Conclusion
IAI of PRP is effective for relieving pain and improving activities of daily living and quality of life in old patients with late-stage knee osteoarthritis. IAI of one shot of corticosteroid has similar results but for a short term and with more side effects. |
| first_indexed | 2024-04-24T14:35:11Z |
| format | Article |
| id | doaj.art-3b823d1d0066484484caf00b6fc4d57c |
| institution | Directory Open Access Journal |
| issn | 2537-091X 2537-0928 |
| language | English |
| last_indexed | 2024-04-24T14:35:11Z |
| publishDate | 2018-01-01 |
| publisher | General Organization of Teaching Hospitals and Institutes |
| record_format | Article |
| series | Journal of Medicine in Scientific Research |
| spelling | doaj.art-3b823d1d0066484484caf00b6fc4d57c2024-04-03T00:33:15ZengGeneral Organization of Teaching Hospitals and InstitutesJournal of Medicine in Scientific Research2537-091X2537-09282018-01-011427828410.4103/JMISR.JMISR_66_18Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritisAbeer H IsmaielObjective The objective of this study was to compare intra-articular injections (IAIs) of platelet-rich plasma (PRP) and corticosteroid injections in reducing pain and studying which has a more effective and lasting functional improvement. Patients and methods A total of 60 patients with chronic knee osteoarthritis (Kellgren–Lawrence grades 3 and 4) were enrolled in this study. Patients were randomized to treatment either with a single leukocyte-rich PRP or corticosteroid IAIs. Patients were assessed by visual analog scale, and Knee injury and Osteoarthritis Outcome Score at 1, 3, and 6 months after treatment. Results Our results showed improvement in all variables in both groups. Statistical differences between groups were found for the majority of the outcome variables, and the degree of improvement was more in the PRP group. Conclusion IAI of PRP is effective for relieving pain and improving activities of daily living and quality of life in old patients with late-stage knee osteoarthritis. IAI of one shot of corticosteroid has similar results but for a short term and with more side effects.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=4;spage=278;epage=284;aulast=Ismaielintra-articular injectionskneeosteoarthritisplatelet-rich plasma |
| spellingShingle | Abeer H Ismaiel Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis Journal of Medicine in Scientific Research intra-articular injections knee osteoarthritis platelet-rich plasma |
| title | Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis |
| title_full | Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis |
| title_fullStr | Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis |
| title_full_unstemmed | Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis |
| title_short | Comparison between the effect of intra-articular injections of platelet-rich plasma and corticosteroids in advanced knee osteoarthritis |
| title_sort | comparison between the effect of intra articular injections of platelet rich plasma and corticosteroids in advanced knee osteoarthritis |
| topic | intra-articular injections knee osteoarthritis platelet-rich plasma |
| url | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=4;spage=278;epage=284;aulast=Ismaiel |
| work_keys_str_mv | AT abeerhismaiel comparisonbetweentheeffectofintraarticularinjectionsofplateletrichplasmaandcorticosteroidsinadvancedkneeosteoarthritis |