Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features
Breast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Federation of Turkish Pathology Societies
2021-05-01
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| Series: | Türk Patoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkjpath.org/pdf.php3?id=1948
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| _version_ | 1797920625149345792 |
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| author | Mohamed JASSIM Chennagiri S PREMALATA Geeta V Patil OKALY Chunduri SRINIVAS |
| author_facet | Mohamed JASSIM Chennagiri S PREMALATA Geeta V Patil OKALY Chunduri SRINIVAS |
| author_sort | Mohamed JASSIM |
| collection | DOAJ |
| description | Breast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papillary thyroid carcinoma but has a distinct morphological, immunohistochemical, and molecular profile. We describe a case of a 40-year-old female patient, who presented with lump in the breast. The patient underwent lumpectomy and was diagnosed as tall cell carcinoma with reverse polarity. Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis. |
| first_indexed | 2024-04-10T14:04:08Z |
| format | Article |
| id | doaj.art-3b82b36f0f0a44f6a09564b7f5a5cfd8 |
| institution | Directory Open Access Journal |
| issn | 1018-5615 1309-5730 |
| language | English |
| last_indexed | 2024-04-10T14:04:08Z |
| publishDate | 2021-05-01 |
| publisher | Federation of Turkish Pathology Societies |
| record_format | Article |
| series | Türk Patoloji Dergisi |
| spelling | doaj.art-3b82b36f0f0a44f6a09564b7f5a5cfd82023-02-15T16:10:05ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302021-05-0137218318810.5146/tjpath.2020.01511Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular FeaturesMohamed JASSIMChennagiri S PREMALATAGeeta V Patil OKALYChunduri SRINIVASBreast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papillary thyroid carcinoma but has a distinct morphological, immunohistochemical, and molecular profile. We describe a case of a 40-year-old female patient, who presented with lump in the breast. The patient underwent lumpectomy and was diagnosed as tall cell carcinoma with reverse polarity. Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis. http://www.turkjpath.org/pdf.php3?id=1948 breast carcinomatall cell carcinomareverse polaritysolid papillaryidh2 |
| spellingShingle | Mohamed JASSIM Chennagiri S PREMALATA Geeta V Patil OKALY Chunduri SRINIVAS Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features Türk Patoloji Dergisi breast carcinoma tall cell carcinoma reverse polarity solid papillary idh2 |
| title | Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features |
| title_full | Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features |
| title_fullStr | Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features |
| title_full_unstemmed | Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features |
| title_short | Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features |
| title_sort | tall cell carcinoma with reverse polarity of breast report of a case with unique morphologic and molecular features |
| topic | breast carcinoma tall cell carcinoma reverse polarity solid papillary idh2 |
| url |
http://www.turkjpath.org/pdf.php3?id=1948
|
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