Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
<p>Abstract</p> <p>Purpose</p> <p>We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM).</p> <p>Patients and Methods</p> <p>Between January 1991 and Ja...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.ro-journal.com/content/6/1/117 |
| _version_ | 1818508988804759552 |
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| author | Debus Jürgen Rieken Stefan Welzel Thomas Adeberg Sebastian Combs Stephanie E |
| author_facet | Debus Jürgen Rieken Stefan Welzel Thomas Adeberg Sebastian Combs Stephanie E |
| author_sort | Debus Jürgen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Purpose</p> <p>We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM).</p> <p>Patients and Methods</p> <p>Between January 1991 and January 2010, 40 patients with ONSM were treated using FSRT. Of these, 19 patients received radiotherapy as primary treatment, and 21 patients were treated after surgical resection. The median target volume was 9.2 ml, median total dose was 54 Gy in median single fractions of 1,8 Gy.</p> <p>Results</p> <p>Local progression-free survival was 100%. Median survival after FSRT was 60 months (range 4-228 months). In all patients overall toleration of FSRT was very good. Acute toxicity was mild. Prior to RT, 29 patients complained about any kind of visual impairment including visual field deficits, diplopia or amaurosis. Prior surgical resection was identified as a negative prognostic factor for visual outcome, whereas patients with larger tumor volumes demonstrated a higher number of patients with improvement of pre-existing visual deficits.</p> <p>Conclusion</p> <p>Long-term outcome after FSRT for ONSM shows improved vision in patients not treated surgically prior to RT; moreover, the best improvement of visual deficits are observed in patients with larger target volumes. The absence of tumor recurrences supports that FSRT is a strong alternative to surgical resection especially in small tumors without extensive compression of normal tissue structures</p> |
| first_indexed | 2024-12-10T22:39:25Z |
| format | Article |
| id | doaj.art-3b8340f791cc4083bd046151af91209c |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-10T22:39:25Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-3b8340f791cc4083bd046151af91209c2022-12-22T01:30:45ZengBMCRadiation Oncology1748-717X2011-09-016111710.1186/1748-717X-6-117Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)Debus JürgenRieken StefanWelzel ThomasAdeberg SebastianCombs Stephanie E<p>Abstract</p> <p>Purpose</p> <p>We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM).</p> <p>Patients and Methods</p> <p>Between January 1991 and January 2010, 40 patients with ONSM were treated using FSRT. Of these, 19 patients received radiotherapy as primary treatment, and 21 patients were treated after surgical resection. The median target volume was 9.2 ml, median total dose was 54 Gy in median single fractions of 1,8 Gy.</p> <p>Results</p> <p>Local progression-free survival was 100%. Median survival after FSRT was 60 months (range 4-228 months). In all patients overall toleration of FSRT was very good. Acute toxicity was mild. Prior to RT, 29 patients complained about any kind of visual impairment including visual field deficits, diplopia or amaurosis. Prior surgical resection was identified as a negative prognostic factor for visual outcome, whereas patients with larger tumor volumes demonstrated a higher number of patients with improvement of pre-existing visual deficits.</p> <p>Conclusion</p> <p>Long-term outcome after FSRT for ONSM shows improved vision in patients not treated surgically prior to RT; moreover, the best improvement of visual deficits are observed in patients with larger target volumes. The absence of tumor recurrences supports that FSRT is a strong alternative to surgical resection especially in small tumors without extensive compression of normal tissue structures</p>http://www.ro-journal.com/content/6/1/117Meningiomavisual outcometoxicitylocal control |
| spellingShingle | Debus Jürgen Rieken Stefan Welzel Thomas Adeberg Sebastian Combs Stephanie E Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) Radiation Oncology Meningioma visual outcome toxicity local control |
| title | Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) |
| title_full | Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) |
| title_fullStr | Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) |
| title_full_unstemmed | Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) |
| title_short | Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM) |
| title_sort | prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas onsm |
| topic | Meningioma visual outcome toxicity local control |
| url | http://www.ro-journal.com/content/6/1/117 |
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