Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study
Abstract Background Effective screening and treatment have reduced the number of women dying from breast cancer (BC). However, the long-term sequelae of BC treatment and psychosocial factors seriously affect the life quality of BC patients and survivors. Therefore, the discovery and application of t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10617-8 |
| _version_ | 1797864414664196096 |
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| author | Yan Wang Lili Du Jiexian Jing Xianwen Zhao Xing Wang Shenghuai Hou |
| author_facet | Yan Wang Lili Du Jiexian Jing Xianwen Zhao Xing Wang Shenghuai Hou |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Abstract Background Effective screening and treatment have reduced the number of women dying from breast cancer (BC). However, the long-term sequelae of BC treatment and psychosocial factors seriously affect the life quality of BC patients and survivors. Therefore, the discovery and application of targeted biomarkers to improve the functional outcome and life quality of BC patients is necessary. Aims To explore the impact of leptin (LEP)/ leptin receptor (LEPR) expression on occurrence and survival of BC. Methods Totally 132 primary BC and 66 non-BC patients who underwent surgery in department of breast surgery in Shanxi Cancer Hospital from January to October in 2009 were enrolled in this retrospective study. LEP and LEPR were examined in BC tissues, benign breast tissues, para-carcinoma tissues using immunohistochemical staining. Kaplan–Meier curve was generated to test survival time. Results The high level expression of LEP and LEPR in BC tissues were significantly higher than that in benign breast tissues and in para-carcinoma tissues (all P < 0.05). The LEP expression in patients with lymph node metastases was significantly higher than that in patients without lymph nodes metastases (P = 0.002). LEPR expression was correlated with higher Ki-67 rate (P = 0.002). LEP and LEPR both had no impact on survival (all P > 0.05). Conclusions High LEP/LEPR expression were risk factors for occurrence of BC, but without impact on survival. |
| first_indexed | 2024-04-09T22:52:39Z |
| format | Article |
| id | doaj.art-3b84db399e68439597e5a531fa99234b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-09T22:52:39Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-3b84db399e68439597e5a531fa99234b2023-03-22T11:34:33ZengBMCBMC Cancer1471-24072023-03-012311810.1186/s12885-023-10617-8Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective studyYan Wang0Lili Du1Jiexian Jing2Xianwen Zhao3Xing Wang4Shenghuai Hou5Department of Etiology and Tumor Markers Laboratory, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesDepartment of Etiology and Tumor Markers Laboratory, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesDepartment of Etiology and Tumor Markers Laboratory, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesDepartment of Etiology and Tumor Markers Laboratory, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesDepartment of Etiology and Tumor Markers Laboratory, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesDepartment of Colorectal and Anal Surgery, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical SciencesAbstract Background Effective screening and treatment have reduced the number of women dying from breast cancer (BC). However, the long-term sequelae of BC treatment and psychosocial factors seriously affect the life quality of BC patients and survivors. Therefore, the discovery and application of targeted biomarkers to improve the functional outcome and life quality of BC patients is necessary. Aims To explore the impact of leptin (LEP)/ leptin receptor (LEPR) expression on occurrence and survival of BC. Methods Totally 132 primary BC and 66 non-BC patients who underwent surgery in department of breast surgery in Shanxi Cancer Hospital from January to October in 2009 were enrolled in this retrospective study. LEP and LEPR were examined in BC tissues, benign breast tissues, para-carcinoma tissues using immunohistochemical staining. Kaplan–Meier curve was generated to test survival time. Results The high level expression of LEP and LEPR in BC tissues were significantly higher than that in benign breast tissues and in para-carcinoma tissues (all P < 0.05). The LEP expression in patients with lymph node metastases was significantly higher than that in patients without lymph nodes metastases (P = 0.002). LEPR expression was correlated with higher Ki-67 rate (P = 0.002). LEP and LEPR both had no impact on survival (all P > 0.05). Conclusions High LEP/LEPR expression were risk factors for occurrence of BC, but without impact on survival.https://doi.org/10.1186/s12885-023-10617-8Breast cancerLeptinLeptin receptorSurvival |
| spellingShingle | Yan Wang Lili Du Jiexian Jing Xianwen Zhao Xing Wang Shenghuai Hou Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study BMC Cancer Breast cancer Leptin Leptin receptor Survival |
| title | Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study |
| title_full | Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study |
| title_fullStr | Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study |
| title_full_unstemmed | Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study |
| title_short | Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study |
| title_sort | leptin and leptin receptor expression as biomarkers for breast cancer a retrospective study |
| topic | Breast cancer Leptin Leptin receptor Survival |
| url | https://doi.org/10.1186/s12885-023-10617-8 |
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