FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells

FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells

Summary: Adaptive human natural killer (NK) cells display significantly enhanced responsiveness to a broad-range of antibody-bound targets through the engagement of CD16 compared to conventional NK cells, yet direct reactivity against tumor targets is generally reduced. Adaptive NK cells also displa...

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Bibliographic Details
Main Authors: Weiru Liu, Jeannine M. Scott, Emma Langguth, Helena Chang, Peter H. Park, Sungjin Kim
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309068

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