Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration
The outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/9/376 |
| _version_ | 1797579497770319872 |
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| author | Cristina Sanchez-Fernandez Lara Rodriguez-Outeiriño Lidia Matias-Valiente Felicitas Ramírez de Acuña Diego Franco Amelia Eva Aránega |
| author_facet | Cristina Sanchez-Fernandez Lara Rodriguez-Outeiriño Lidia Matias-Valiente Felicitas Ramírez de Acuña Diego Franco Amelia Eva Aránega |
| author_sort | Cristina Sanchez-Fernandez |
| collection | DOAJ |
| description | The outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the adult epicardium reactivates and recapitulates many aspects of embryonic cardiogenesis in response to cardiac injury, thereby supporting cardiac tissue remodeling. Thus, the epicardium has been considered a crucial source of cell progenitors that offers an important contribution to cardiac development and injured hearts. Although several studies have provided evidence regarding cell fate determination in the epicardium, to date, it is unclear whether epicardium-derived cells (EPDCs) come from specific, and predetermined, epicardial cell subpopulations or if they are derived from a common progenitor. In recent years, different approaches have been used to study cell heterogeneity within the epicardial layer using different experimental models. However, the data generated are still insufficient with respect to revealing the complexity of this epithelial layer. In this review, we summarize the previous works documenting the cellular composition, molecular signatures, and diversity within the developing and adult epicardium. |
| first_indexed | 2024-03-10T22:38:00Z |
| format | Article |
| id | doaj.art-3b85bea683a649b8a42f9d7f6fe0bbec |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T22:38:00Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-3b85bea683a649b8a42f9d7f6fe0bbec2023-11-19T11:16:34ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-09-0110937610.3390/jcdd10090376Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart RegenerationCristina Sanchez-Fernandez0Lara Rodriguez-Outeiriño1Lidia Matias-Valiente2Felicitas Ramírez de Acuña3Diego Franco4Amelia Eva Aránega5Cardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainCardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainCardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainCardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainCardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainCardiovascular Development Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, 23071 Jaén, SpainThe outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the adult epicardium reactivates and recapitulates many aspects of embryonic cardiogenesis in response to cardiac injury, thereby supporting cardiac tissue remodeling. Thus, the epicardium has been considered a crucial source of cell progenitors that offers an important contribution to cardiac development and injured hearts. Although several studies have provided evidence regarding cell fate determination in the epicardium, to date, it is unclear whether epicardium-derived cells (EPDCs) come from specific, and predetermined, epicardial cell subpopulations or if they are derived from a common progenitor. In recent years, different approaches have been used to study cell heterogeneity within the epicardial layer using different experimental models. However, the data generated are still insufficient with respect to revealing the complexity of this epithelial layer. In this review, we summarize the previous works documenting the cellular composition, molecular signatures, and diversity within the developing and adult epicardium.https://www.mdpi.com/2308-3425/10/9/376epicardiumheterogeneitycardiac developmentcardiac repair |
| spellingShingle | Cristina Sanchez-Fernandez Lara Rodriguez-Outeiriño Lidia Matias-Valiente Felicitas Ramírez de Acuña Diego Franco Amelia Eva Aránega Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration Journal of Cardiovascular Development and Disease epicardium heterogeneity cardiac development cardiac repair |
| title | Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration |
| title_full | Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration |
| title_fullStr | Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration |
| title_full_unstemmed | Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration |
| title_short | Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration |
| title_sort | understanding epicardial cell heterogeneity during cardiogenesis and heart regeneration |
| topic | epicardium heterogeneity cardiac development cardiac repair |
| url | https://www.mdpi.com/2308-3425/10/9/376 |
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