The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness
Abstract Background Gout is a common inflammatory arthritis caused by increased serum uric acid levels. Untreated or insufficiently treated gout can lead to deposition of monosodium urate crystals in joints, cartilage, and kidneys. Although Tongfengding capsules, a Chinese patent medicine, have long...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-023-00310-6 |
| _version_ | 1797773876309000192 |
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| author | Qiaoli Hua Xusheng Liu Yang Luo Yujie Lin Kairong Zheng Ai Xia Qianchun Yang |
| author_facet | Qiaoli Hua Xusheng Liu Yang Luo Yujie Lin Kairong Zheng Ai Xia Qianchun Yang |
| author_sort | Qiaoli Hua |
| collection | DOAJ |
| description | Abstract Background Gout is a common inflammatory arthritis caused by increased serum uric acid levels. Untreated or insufficiently treated gout can lead to deposition of monosodium urate crystals in joints, cartilage, and kidneys. Although Tongfengding capsules, a Chinese patent medicine, have long been used to treat gout, their effects and safety have not been reviewed systematically. This study evaluated its efficacy and safety for gout in adults. Methods Randomized controlled trials involving Tongfengding capsule for gout in adults were searched from PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CBM, CNKI, and VIP databases, and analyzed using the Cochrane Handbook criteria. The primary outcome measures were the total effective rate. The secondary outcome measures including the blood uric acid (BUA), 24-h urinary total protein (24-h UTP), blood urea nitrogen (BUN), interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) and adverse effects. The risk of bias was evaluated in all included studies. RevMan ver. 5.3.5 and GRADE profiler was used for data analysis and assessing the quality of evidence, respectively. Results Six studies (n = 607 Chinese participants) were included. Tongfengding capsules plus conventional treatment significantly increased the total effective rate (RR 1.21, 95% CI 1.11–1.33), while reducing the BUA (MD − 66.05 µmol/L, 95% CI − 81.26 to − 50.84), 24-h UTP (MD − 0.83 g/24 h, 95% CI − 0.96 to − 0.70), BUN (MD − 0.90 mmol/L, 95% CI − 1.60 to − 0.20), IL-6 (MD − 6.99 ng/L, 95% CI − 13.22 to − 0.75), IL-8 (MD − 12.17 ng/L, 95% CI − 18.07 to − 6.27), TNF-α (MD − 8.50 ng/L, 95% CI − 15.50 to − 1.51), and adverse effects (RR 0.21, 95% CI 0.04–0.95). Conclusion Tongfengding capsules plus conventional treatment is safe and beneficial for adults with gout compared with conventional treatment. |
| first_indexed | 2024-03-12T22:12:15Z |
| format | Article |
| id | doaj.art-3b875ab7a40f4bf59a990e689f11bb79 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-03-12T22:12:15Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-3b875ab7a40f4bf59a990e689f11bb792023-07-23T11:30:05ZengBMCAdvances in Rheumatology2523-31062023-07-0163111710.1186/s42358-023-00310-6The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectivenessQiaoli Hua0Xusheng Liu1Yang Luo2Yujie Lin3Kairong Zheng4Ai Xia5Qianchun Yang6The Second Clinical Medical College, Guangzhou University of Chinese MedicineDepartment of Nephrology, Guangdong Provincial Hospital of Chinese MedicineThe First Clinical Medical College, Guangzhou University of Chinese MedicineThe Second Clinical Medical College, Guangzhou University of Chinese MedicineDepartment of Nephrology, General Hospital of Southern Theatre Command, PLAThe Second Clinical Medical College, Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineAbstract Background Gout is a common inflammatory arthritis caused by increased serum uric acid levels. Untreated or insufficiently treated gout can lead to deposition of monosodium urate crystals in joints, cartilage, and kidneys. Although Tongfengding capsules, a Chinese patent medicine, have long been used to treat gout, their effects and safety have not been reviewed systematically. This study evaluated its efficacy and safety for gout in adults. Methods Randomized controlled trials involving Tongfengding capsule for gout in adults were searched from PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CBM, CNKI, and VIP databases, and analyzed using the Cochrane Handbook criteria. The primary outcome measures were the total effective rate. The secondary outcome measures including the blood uric acid (BUA), 24-h urinary total protein (24-h UTP), blood urea nitrogen (BUN), interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) and adverse effects. The risk of bias was evaluated in all included studies. RevMan ver. 5.3.5 and GRADE profiler was used for data analysis and assessing the quality of evidence, respectively. Results Six studies (n = 607 Chinese participants) were included. Tongfengding capsules plus conventional treatment significantly increased the total effective rate (RR 1.21, 95% CI 1.11–1.33), while reducing the BUA (MD − 66.05 µmol/L, 95% CI − 81.26 to − 50.84), 24-h UTP (MD − 0.83 g/24 h, 95% CI − 0.96 to − 0.70), BUN (MD − 0.90 mmol/L, 95% CI − 1.60 to − 0.20), IL-6 (MD − 6.99 ng/L, 95% CI − 13.22 to − 0.75), IL-8 (MD − 12.17 ng/L, 95% CI − 18.07 to − 6.27), TNF-α (MD − 8.50 ng/L, 95% CI − 15.50 to − 1.51), and adverse effects (RR 0.21, 95% CI 0.04–0.95). Conclusion Tongfengding capsules plus conventional treatment is safe and beneficial for adults with gout compared with conventional treatment.https://doi.org/10.1186/s42358-023-00310-6Chinese patent medicineTongfengding capsuleGoutRandomized controlled trialsSystematic review |
| spellingShingle | Qiaoli Hua Xusheng Liu Yang Luo Yujie Lin Kairong Zheng Ai Xia Qianchun Yang The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness Advances in Rheumatology Chinese patent medicine Tongfengding capsule Gout Randomized controlled trials Systematic review |
| title | The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness |
| title_full | The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness |
| title_fullStr | The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness |
| title_full_unstemmed | The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness |
| title_short | The Chinese patent medicine Tongfengding capsule for gout in adults: a systematic review of safety and effectiveness |
| title_sort | chinese patent medicine tongfengding capsule for gout in adults a systematic review of safety and effectiveness |
| topic | Chinese patent medicine Tongfengding capsule Gout Randomized controlled trials Systematic review |
| url | https://doi.org/10.1186/s42358-023-00310-6 |
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