Risk of liver fibrosis in patients with prediabetes and diabetes mellitus.
The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classifie...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0269070 |
| _version_ | 1828330045668589568 |
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| author | Jongsin Park Heon-Ju Kwon Won Sohn Ju-Yeon Cho Soo Jin Park Yoosoo Chang Seungho Ryu Byung Ik Kim Yong Kyun Cho |
| author_facet | Jongsin Park Heon-Ju Kwon Won Sohn Ju-Yeon Cho Soo Jin Park Yoosoo Chang Seungho Ryu Byung Ik Kim Yong Kyun Cho |
| author_sort | Jongsin Park |
| collection | DOAJ |
| description | The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57-5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59-1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease. |
| first_indexed | 2024-04-13T20:34:07Z |
| format | Article |
| id | doaj.art-3b8800c902c94364a055fb528400b4f6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T20:34:07Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b8800c902c94364a055fb528400b4f62022-12-22T02:31:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176e026907010.1371/journal.pone.0269070Risk of liver fibrosis in patients with prediabetes and diabetes mellitus.Jongsin ParkHeon-Ju KwonWon SohnJu-Yeon ChoSoo Jin ParkYoosoo ChangSeungho RyuByung Ik KimYong Kyun ChoThe aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57-5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59-1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease.https://doi.org/10.1371/journal.pone.0269070 |
| spellingShingle | Jongsin Park Heon-Ju Kwon Won Sohn Ju-Yeon Cho Soo Jin Park Yoosoo Chang Seungho Ryu Byung Ik Kim Yong Kyun Cho Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. PLoS ONE |
| title | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| title_full | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| title_fullStr | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| title_full_unstemmed | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| title_short | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| title_sort | risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
| url | https://doi.org/10.1371/journal.pone.0269070 |
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