Treatment of chronic insomnia with atypical antipsychotics: results from a follow-up study
Objective: Second generation (atypical) antipsychotics are increasingly being used for treatment of insomnia, but there is little evidence to show long-term efficacy of these medication. This followup study was designed to assess patients with chronic insomnia who were treate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2021-03-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | https://sleepscience.org.br/export-pdf/2907/v14n1a05.pdf |
| Summary: | Objective: Second generation (atypical) antipsychotics are increasingly being used for treatment of
insomnia, but there is little evidence to show long-term efficacy of these medication. This followup
study was designed to assess patients with chronic insomnia who were treated with atypical
antipsychotics. Material and Methods: In this follow-up study, forty patients with chronic insomnia
were evaluated between 2016 and 2018 following after one year of treatment with two atypical
antipsychotic drugs of olanzapine and quetiapine in two groups in the sleep disorders research center
of Kermanshah University of Medical Science in Iran. The Pittsburgh Sleep Quality Questionnaire
(PSQI) and 5 consecutive nights of Actigraphy were utilized to evaluate both subjective and objective
measures of sleep quality. Lastly, sleep quality before and after treatment and comparisons of
sleep quality between the two groups were performed. Results: Nine male participants comprised
olanzapine group (n=22) and six male participants comprised the quetiapine group (n=18). The
average age in the olanzapine group was 45.23±10.18 and the average age in the quetiapine group
was 46.33±7.99. Results showed total PSQI score improved significantly in both groups (p<0.05),
while the actigraphy results showed only significant improvement in sleep quality parameters in
the quetiapine group (p<0.05). Conclusion: Two atypical antipsychotics drugs of olanzapine and
quetiapine have long-term efficacy in managing chronic insomnia. More improvements in objective
sleep quality with quetiapine is promising for patients with chronic insomnia. Further research to
evaluate long-term adverse effects of atypical antipsychotic drugs is recommended. |
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| ISSN: | 1984-0659 1984-0063 |