DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice
Male and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04643-2 |
| _version_ | 1797863795664617472 |
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| author | Laura Senatus Lander Egaña-Gorroño Raquel López-Díez Sonia Bergaya Juan Francisco Aranda Jaume Amengual Lakshmi Arivazhagan Michaele B. Manigrasso Gautham Yepuri Ramesh Nimma Kaamashri N. Mangar Rollanda Bernadin Boyan Zhou Paul F. Gugger Huilin Li Richard A. Friedman Neil D. Theise Alexander Shekhtman Edward A. Fisher Ravichandran Ramasamy Ann Marie Schmidt |
| author_facet | Laura Senatus Lander Egaña-Gorroño Raquel López-Díez Sonia Bergaya Juan Francisco Aranda Jaume Amengual Lakshmi Arivazhagan Michaele B. Manigrasso Gautham Yepuri Ramesh Nimma Kaamashri N. Mangar Rollanda Bernadin Boyan Zhou Paul F. Gugger Huilin Li Richard A. Friedman Neil D. Theise Alexander Shekhtman Edward A. Fisher Ravichandran Ramasamy Ann Marie Schmidt |
| author_sort | Laura Senatus |
| collection | DOAJ |
| description | Male and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization. |
| first_indexed | 2024-04-09T22:42:27Z |
| format | Article |
| id | doaj.art-3b884c6d0ad746b0ae3401514cb0c693 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-09T22:42:27Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-3b884c6d0ad746b0ae3401514cb0c6932023-03-22T12:04:28ZengNature PortfolioCommunications Biology2399-36422023-03-016112010.1038/s42003-023-04643-2DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in miceLaura Senatus0Lander Egaña-Gorroño1Raquel López-Díez2Sonia Bergaya3Juan Francisco Aranda4Jaume Amengual5Lakshmi Arivazhagan6Michaele B. Manigrasso7Gautham Yepuri8Ramesh Nimma9Kaamashri N. Mangar10Rollanda Bernadin11Boyan Zhou12Paul F. Gugger13Huilin Li14Richard A. Friedman15Neil D. Theise16Alexander Shekhtman17Edward A. Fisher18Ravichandran Ramasamy19Ann Marie Schmidt20Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthThe Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthThe Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDepartment of Population Health, Division of Biostatistics, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDepartment of Population Health, Division of Biostatistics, NYU Grossman School of Medicine, NYU Langone HealthBiomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center and Department of Biomedical Informatics, Columbia University Irving Medical CenterDepartment of Pathology, NYU Grossman School of Medicine, NYU Langone HealthDepartment of Chemistry, The State University of New York at AlbanyThe Leon H. Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthDiabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, NYU Langone HealthMale and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization.https://doi.org/10.1038/s42003-023-04643-2 |
| spellingShingle | Laura Senatus Lander Egaña-Gorroño Raquel López-Díez Sonia Bergaya Juan Francisco Aranda Jaume Amengual Lakshmi Arivazhagan Michaele B. Manigrasso Gautham Yepuri Ramesh Nimma Kaamashri N. Mangar Rollanda Bernadin Boyan Zhou Paul F. Gugger Huilin Li Richard A. Friedman Neil D. Theise Alexander Shekhtman Edward A. Fisher Ravichandran Ramasamy Ann Marie Schmidt DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice Communications Biology |
| title | DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| title_full | DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| title_fullStr | DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| title_full_unstemmed | DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| title_short | DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| title_sort | diaph1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice |
| url | https://doi.org/10.1038/s42003-023-04643-2 |
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