The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Some evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function mark...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4577 |
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| author | Abril I. Sánchez-Rosales Ana L. Guadarrama-López Laura S. Gaona-Valle Beatriz E. Martínez-Carrillo Roxana Valdés-Ramos |
| author_facet | Abril I. Sánchez-Rosales Ana L. Guadarrama-López Laura S. Gaona-Valle Beatriz E. Martínez-Carrillo Roxana Valdés-Ramos |
| author_sort | Abril I. Sánchez-Rosales |
| collection | DOAJ |
| description | Some evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function markers could indicate an ongoing pathology. Following certain dietary patterns (DPs) may result in favorable changes in inflammatory biomarkers. The overarching aim of this systematic review and meta-analysis is to explore the inflammatory effect of healthy DPs on inflammatory biomarkers in adults with T2DM. A systematic search of the literature was conducted using the electronic databases MEDLINE, SCOPUS, and Cochrane Central Register of Controlled Trials. A total of 10 randomized controlled clinical trials (RCTs) were analyzed. In our linear meta-analysis, the random-effects model was applied to estimate standardized mean differences (SMD) to associate the effect of the interventions. Dietary Approaches to Stop Hypertension (DASH), Diabetes UK healthy eating, Mediterranean Diet (MD), Diabetes Prevention Program (DPP), and the American Heart Association’s Therapeutic Lifestyle Changes diet were associated with a significant reduction in CRP (SMD: −0.83, 99% CI −1.49, −0.17, <i>p</i> < 0.001; I<sup>2</sup> 94%), while plasma levels of adiponectin were significantly higher with the intake of MD, DPP, and Diabetes UK healthy eating (SMD: 0.81, 99% CI 0.06,1.56, <i>p</i> < 0.005; I<sup>2</sup> 96%), both of which indicate less inflammation. Sensitivity analyses were carried out, and potential publication bias was examined. In conclusion, low- moderate-quality evidence from RCTs suggests that, for the DPs evaluated, there are favorable changes in CRP and adiponectin. |
| first_indexed | 2024-03-09T18:45:52Z |
| format | Article |
| id | doaj.art-3b8a715a8fb34373bb7a3c45e411691e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:45:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3b8a715a8fb34373bb7a3c45e411691e2023-11-24T06:13:47ZengMDPI AGNutrients2072-66432022-10-011421457710.3390/nu14214577The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsAbril I. Sánchez-Rosales0Ana L. Guadarrama-López1Laura S. Gaona-Valle2Beatriz E. Martínez-Carrillo3Roxana Valdés-Ramos4Faculty of Medicine, Universidad Autónoma del Estado de México, Toluca 50180, MexicoMultidisciplinary Clinic of Health, Universidad Autónoma del Estado de México, Toluca 50180, MexicoCentro Médico Lic. Adolfo López Mateos, Instituto de Salud del Estado de México (ISEM), Toluca 50010, MexicoFaculty of Medicine, Universidad Autónoma del Estado de México, Toluca 50180, MexicoFaculty of Medicine, Universidad Autónoma del Estado de México, Toluca 50180, MexicoSome evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function markers could indicate an ongoing pathology. Following certain dietary patterns (DPs) may result in favorable changes in inflammatory biomarkers. The overarching aim of this systematic review and meta-analysis is to explore the inflammatory effect of healthy DPs on inflammatory biomarkers in adults with T2DM. A systematic search of the literature was conducted using the electronic databases MEDLINE, SCOPUS, and Cochrane Central Register of Controlled Trials. A total of 10 randomized controlled clinical trials (RCTs) were analyzed. In our linear meta-analysis, the random-effects model was applied to estimate standardized mean differences (SMD) to associate the effect of the interventions. Dietary Approaches to Stop Hypertension (DASH), Diabetes UK healthy eating, Mediterranean Diet (MD), Diabetes Prevention Program (DPP), and the American Heart Association’s Therapeutic Lifestyle Changes diet were associated with a significant reduction in CRP (SMD: −0.83, 99% CI −1.49, −0.17, <i>p</i> < 0.001; I<sup>2</sup> 94%), while plasma levels of adiponectin were significantly higher with the intake of MD, DPP, and Diabetes UK healthy eating (SMD: 0.81, 99% CI 0.06,1.56, <i>p</i> < 0.005; I<sup>2</sup> 96%), both of which indicate less inflammation. Sensitivity analyses were carried out, and potential publication bias was examined. In conclusion, low- moderate-quality evidence from RCTs suggests that, for the DPs evaluated, there are favorable changes in CRP and adiponectin.https://www.mdpi.com/2072-6643/14/21/4577type 2 diabetes mellituschronic inflammationbiomarkers of inflammationdietary patternsMediterranean Diet |
| spellingShingle | Abril I. Sánchez-Rosales Ana L. Guadarrama-López Laura S. Gaona-Valle Beatriz E. Martínez-Carrillo Roxana Valdés-Ramos The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Nutrients type 2 diabetes mellitus chronic inflammation biomarkers of inflammation dietary patterns Mediterranean Diet |
| title | The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | effect of dietary patterns on inflammatory biomarkers in adults with type 2 diabetes mellitus a systematic review and meta analysis of randomized controlled trials |
| topic | type 2 diabetes mellitus chronic inflammation biomarkers of inflammation dietary patterns Mediterranean Diet |
| url | https://www.mdpi.com/2072-6643/14/21/4577 |
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