Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells

Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells

<i>Background:</i> Extensive research has reported that extracellular ADP in the tumour microenvironment can stimulate platelets through interaction with the platelet receptor P2Y12. In turn, activated platelets release biological factors supporting cancer progression. Experimental data...

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Bibliographic Details
Main Authors: Omar Elaskalani, Alice Domenichini, Norbaini Binti Abdol Razak, Danielle E. Dye, Marco Falasca, Pat Metharom
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
antiplatelet drug
chemoresistance
p2y12
pancreatic cancer
adp
Online Access:https://www.mdpi.com/2072-6694/12/1/250

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