The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial
Abstract Background Peritonitis is one of the major complications of peritoneal dialysis. The most common cause of peritonitis is infection at the catheter exit site. This study aimed to determine the effect of propolis on the incidence of catheter exit site infection and peritonitis in peritoneal d...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-022-03036-7 |
| _version_ | 1797977528964481024 |
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| author | Lila Moghiseh Monir Nobahar Raheb Ghorbani Shiva Sirafian |
| author_facet | Lila Moghiseh Monir Nobahar Raheb Ghorbani Shiva Sirafian |
| author_sort | Lila Moghiseh |
| collection | DOAJ |
| description | Abstract Background Peritonitis is one of the major complications of peritoneal dialysis. The most common cause of peritonitis is infection at the catheter exit site. This study aimed to determine the effect of propolis on the incidence of catheter exit site infection and peritonitis in peritoneal dialysis patients. Method This study was a double-blind clinical trial (2019–2020) with peritoneal dialysis patients. Ninety peritoneal dialysis patients were allocated to three groups (placebo, control, intervention) using block randomization method. Catheter exit site was washed with 0.9% normal saline and dressing was done every other day after the morning peritoneal dialysis exchange by use of normal saline in placebo, mupirocin in control, and propolis in intervention group, for 6 months. Discussion 10% of the patients in the placebo and 6.7% in the control group developed catheter Exit Site Infection, but none patient in the intervention group developed this infection (P = 0.469). Whereas 6.7% in both the placebo and control groups developed peritonitis, but none patient in the intervention group contracted peritonitis (P = 0.997). No significant differences in the incidence of catheter exit site infection and peritonitis among the three groups were observed. Considering that mupirocin is of chemical origin and may lead to drug resistance whereas propolis is of plant origin and does not produce drug resistance, the use of propolis is recommended. Trial registration Iranian Registry of Clinical Trials [ IRCT20110427006318N10 ] (17/01/2019). |
| first_indexed | 2024-04-11T05:08:23Z |
| format | Article |
| id | doaj.art-3b8ac9603bab48bea3fd043762b6281c |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-11T05:08:23Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3b8ac9603bab48bea3fd043762b6281c2022-12-25T12:07:56ZengBMCBMC Nephrology1471-23692022-12-0123111010.1186/s12882-022-03036-7The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trialLila Moghiseh0Monir Nobahar1Raheb Ghorbani2Shiva Sirafian3Nursing Care Research Center, Semnan University of Medical SciencesNursing Care Research Center, Semnan University of Medical SciencesSocial Determinants of Health Research Center, Semnan University of Medical SciencesIsfahan Kidney Diseases Research Center, Internal Medicine Department, Isfahan University of Medical SciencesAbstract Background Peritonitis is one of the major complications of peritoneal dialysis. The most common cause of peritonitis is infection at the catheter exit site. This study aimed to determine the effect of propolis on the incidence of catheter exit site infection and peritonitis in peritoneal dialysis patients. Method This study was a double-blind clinical trial (2019–2020) with peritoneal dialysis patients. Ninety peritoneal dialysis patients were allocated to three groups (placebo, control, intervention) using block randomization method. Catheter exit site was washed with 0.9% normal saline and dressing was done every other day after the morning peritoneal dialysis exchange by use of normal saline in placebo, mupirocin in control, and propolis in intervention group, for 6 months. Discussion 10% of the patients in the placebo and 6.7% in the control group developed catheter Exit Site Infection, but none patient in the intervention group developed this infection (P = 0.469). Whereas 6.7% in both the placebo and control groups developed peritonitis, but none patient in the intervention group contracted peritonitis (P = 0.997). No significant differences in the incidence of catheter exit site infection and peritonitis among the three groups were observed. Considering that mupirocin is of chemical origin and may lead to drug resistance whereas propolis is of plant origin and does not produce drug resistance, the use of propolis is recommended. Trial registration Iranian Registry of Clinical Trials [ IRCT20110427006318N10 ] (17/01/2019).https://doi.org/10.1186/s12882-022-03036-7Catheter exit site infectionClinical trialPeritoneal Dialysis patientsPeritonitisPropolis |
| spellingShingle | Lila Moghiseh Monir Nobahar Raheb Ghorbani Shiva Sirafian The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial BMC Nephrology Catheter exit site infection Clinical trial Peritoneal Dialysis patients Peritonitis Propolis |
| title | The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial |
| title_full | The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial |
| title_fullStr | The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial |
| title_full_unstemmed | The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial |
| title_short | The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial |
| title_sort | impact of propolis on catheter exit site infection and peritonitis in peritoneal dialysis patients a clinical trial |
| topic | Catheter exit site infection Clinical trial Peritoneal Dialysis patients Peritonitis Propolis |
| url | https://doi.org/10.1186/s12882-022-03036-7 |
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