Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia
BACKGROUND: The administration of the coronavirus disease 2019 (COVID-19) vaccine aims to stimulate the production of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies. This leads to an enhanced production of neutralizing antibodies (Nabs), which naturally neutralize the virus...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-02-01
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| Series: | Journal of Education and Health Promotion |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jehp.jehp_886_23 |
| _version_ | 1827168829937025024 |
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| author | Andi Magfirah Hamsi Ridwan Amiruddin A. Arsunan Arsin Andi Zulkifli Abdullah Hasnawati Amqam Shanti Riskiyani |
| author_facet | Andi Magfirah Hamsi Ridwan Amiruddin A. Arsunan Arsin Andi Zulkifli Abdullah Hasnawati Amqam Shanti Riskiyani |
| author_sort | Andi Magfirah Hamsi |
| collection | DOAJ |
| description | BACKGROUND:
The administration of the coronavirus disease 2019 (COVID-19) vaccine aims to stimulate the production of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies. This leads to an enhanced production of neutralizing antibodies (Nabs), which naturally neutralize the virus within the body, thereby reducing the risk of COVID-19 infection. This study determined the analysis of factors affecting SARS-CoV-2 antibody levels in vaccinated individuals using data from the COVID-19 Seroepidemiological Survey of Gowa Regency.
METHODS AND MATERIAL:
This was an analytic observational study with a cross-sectional design. The COVID-19 Seroepidemiology Survey data as a whole were 851 individuals, and in this study, the number of samples was 804 individuals from all COVID-19 Seroepidemiology Survey samples who had performed the COVID-19 vaccine in Gowa Regency, selected through purposive sampling.
STATISTICAL ANALYSIS USED:
Data analysis was conducted using various statistical tests, including the independent-samples t-test, Mann–Whitney test, Kruskal–Wallis test, and multiple logistic regression. Furthermore, the analysis was performed through the STATA program version 14.0.
RESULTS:
There was a significant influence between the history of COVID-19 infection (P = 0.0006) and dose of vaccine (P = 0.0001) with SARS-CoV-2 antibody levels in vaccinated individuals. Meanwhile, vitamin consumption and comorbid history did not affect SARS-CoV-2 antibody levels. Multivariate analysis showed that vaccine dose was the most influential variable on antibody levels (P = 0.046; Odds Ratio (OR) 0.19; 95% Confidence Interval (CI): 0.036–0.968).
CONCLUSIONS:
The most influential factor was the vaccine dose on SARS-CoV-2 antibody levels in community in Gowa Regency. |
| first_indexed | 2024-04-24T19:41:51Z |
| format | Article |
| id | doaj.art-3b8b42f44f4b45e09114cf778dc7a2c8 |
| institution | Directory Open Access Journal |
| issn | 2277-9531 2319-6440 |
| language | English |
| last_indexed | 2025-03-21T02:26:24Z |
| publishDate | 2024-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Education and Health Promotion |
| spelling | doaj.art-3b8b42f44f4b45e09114cf778dc7a2c82024-08-02T14:42:38ZengWolters Kluwer Medknow PublicationsJournal of Education and Health Promotion2277-95312319-64402024-02-01131545410.4103/jehp.jehp_886_23Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, IndonesiaAndi Magfirah HamsiRidwan AmiruddinA. Arsunan ArsinAndi Zulkifli AbdullahHasnawati AmqamShanti RiskiyaniBACKGROUND: The administration of the coronavirus disease 2019 (COVID-19) vaccine aims to stimulate the production of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies. This leads to an enhanced production of neutralizing antibodies (Nabs), which naturally neutralize the virus within the body, thereby reducing the risk of COVID-19 infection. This study determined the analysis of factors affecting SARS-CoV-2 antibody levels in vaccinated individuals using data from the COVID-19 Seroepidemiological Survey of Gowa Regency. METHODS AND MATERIAL: This was an analytic observational study with a cross-sectional design. The COVID-19 Seroepidemiology Survey data as a whole were 851 individuals, and in this study, the number of samples was 804 individuals from all COVID-19 Seroepidemiology Survey samples who had performed the COVID-19 vaccine in Gowa Regency, selected through purposive sampling. STATISTICAL ANALYSIS USED: Data analysis was conducted using various statistical tests, including the independent-samples t-test, Mann–Whitney test, Kruskal–Wallis test, and multiple logistic regression. Furthermore, the analysis was performed through the STATA program version 14.0. RESULTS: There was a significant influence between the history of COVID-19 infection (P = 0.0006) and dose of vaccine (P = 0.0001) with SARS-CoV-2 antibody levels in vaccinated individuals. Meanwhile, vitamin consumption and comorbid history did not affect SARS-CoV-2 antibody levels. Multivariate analysis showed that vaccine dose was the most influential variable on antibody levels (P = 0.046; Odds Ratio (OR) 0.19; 95% Confidence Interval (CI): 0.036–0.968). CONCLUSIONS: The most influential factor was the vaccine dose on SARS-CoV-2 antibody levels in community in Gowa Regency.https://journals.lww.com/10.4103/jehp.jehp_886_23comorbiditiescovid-19 infectionsars-cov-2 antibody levelsvaccine dosevitamin consumption |
| spellingShingle | Andi Magfirah Hamsi Ridwan Amiruddin A. Arsunan Arsin Andi Zulkifli Abdullah Hasnawati Amqam Shanti Riskiyani Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia Journal of Education and Health Promotion comorbidities covid-19 infection sars-cov-2 antibody levels vaccine dose vitamin consumption |
| title | Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia |
| title_full | Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia |
| title_fullStr | Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia |
| title_full_unstemmed | Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia |
| title_short | Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia |
| title_sort | effect of vaccine dose on severe acute respiratory syndrome coronavirus 2 sars cov 2 antibody levels in a vaccinated community in gowa regency indonesia |
| topic | comorbidities covid-19 infection sars-cov-2 antibody levels vaccine dose vitamin consumption |
| url | https://journals.lww.com/10.4103/jehp.jehp_886_23 |
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