Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study
Objective: To evaluate the acute wound healing potential of RDFE cream on type III collagen and EGF levels. Method: Male Albino Wistar rats have randomly divided into three groups: negative control received base cream, positive control administered with 10% zalf povidone and RDFE group was treated w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2020-06-01
|
| Series: | Medicina Clínica Práctica |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2603924920300136 |
| _version_ | 1811286356321632256 |
|---|---|
| author | Takdir Tahir Nur Febrianti Sri Wahyuni Rabia Yuliana Syam |
| author_facet | Takdir Tahir Nur Febrianti Sri Wahyuni Rabia Yuliana Syam |
| author_sort | Takdir Tahir |
| collection | DOAJ |
| description | Objective: To evaluate the acute wound healing potential of RDFE cream on type III collagen and EGF levels. Method: Male Albino Wistar rats have randomly divided into three groups: negative control received base cream, positive control administered with 10% zalf povidone and RDFE group was treated with RDFE cream. The healing effects were assessed on EGF, type III collagen, wound diameter, tissue granulation, and epithelization, for 3, 7, 11, and 14 days post-treatment. Results: On the 3rd-day post-treatment, the greatest reduction in wound diameters were shown significantly in the positive control among groups (p < 0.05). Although the data were statistically insignificant, RDFE groups showed the highest level of type III collagen among groups after 7-day treatment (p > 0.05). Conclusion: The effect of RDFE cream in the wound healing process on type III collagen appeared on day 7. However, an increase of EGF levels was not observed following RDFE treatment. |
| first_indexed | 2024-04-13T02:58:25Z |
| format | Article |
| id | doaj.art-3b8b750c5be04bf9a5815b98ecd5f115 |
| institution | Directory Open Access Journal |
| issn | 2603-9249 |
| language | English |
| last_indexed | 2024-04-13T02:58:25Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Medicina Clínica Práctica |
| spelling | doaj.art-3b8b750c5be04bf9a5815b98ecd5f1152022-12-22T03:05:32ZengElsevier EspañaMedicina Clínica Práctica2603-92492020-06-013100091Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal studyTakdir Tahir0Nur Febrianti1Sri Wahyuni2 Rabia3Yuliana Syam4Department of Medical-Surgical Nursing, Faculty of Nursing, Hasanuddin University, Indonesia; Corresponding author.Department of Medical-Surgical Nursing, School of Nursing Graha Edukasi, IndonesiaDepartment of Medical-Surgical Nursing, School of Nursing Nani Hasanuddin, IndonesiaDepartment of Physiotherapy, Faculty of Nursing, Hasanuddin University, IndonesiaDepartment of Basic Nursing, Faculty of Nursing, Hasanuddin University, IndonesiaObjective: To evaluate the acute wound healing potential of RDFE cream on type III collagen and EGF levels. Method: Male Albino Wistar rats have randomly divided into three groups: negative control received base cream, positive control administered with 10% zalf povidone and RDFE group was treated with RDFE cream. The healing effects were assessed on EGF, type III collagen, wound diameter, tissue granulation, and epithelization, for 3, 7, 11, and 14 days post-treatment. Results: On the 3rd-day post-treatment, the greatest reduction in wound diameters were shown significantly in the positive control among groups (p < 0.05). Although the data were statistically insignificant, RDFE groups showed the highest level of type III collagen among groups after 7-day treatment (p > 0.05). Conclusion: The effect of RDFE cream in the wound healing process on type III collagen appeared on day 7. However, an increase of EGF levels was not observed following RDFE treatment.http://www.sciencedirect.com/science/article/pii/S2603924920300136Hylocereus PolyrhizusType III collagenEGFWound healing |
| spellingShingle | Takdir Tahir Nur Febrianti Sri Wahyuni Rabia Yuliana Syam Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study Medicina Clínica Práctica Hylocereus Polyrhizus Type III collagen EGF Wound healing |
| title | Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study |
| title_full | Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study |
| title_fullStr | Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study |
| title_full_unstemmed | Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study |
| title_short | Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study |
| title_sort | evaluation of acute wound healing potential of red dragon fruit hylocereus polyrhizus extract cream on type iii collagen and epidermal growth factor egf levels an animal study |
| topic | Hylocereus Polyrhizus Type III collagen EGF Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2603924920300136 |
| work_keys_str_mv | AT takdirtahir evaluationofacutewoundhealingpotentialofreddragonfruithylocereuspolyrhizusextractcreamontypeiiicollagenandepidermalgrowthfactoregflevelsananimalstudy AT nurfebrianti evaluationofacutewoundhealingpotentialofreddragonfruithylocereuspolyrhizusextractcreamontypeiiicollagenandepidermalgrowthfactoregflevelsananimalstudy AT sriwahyuni evaluationofacutewoundhealingpotentialofreddragonfruithylocereuspolyrhizusextractcreamontypeiiicollagenandepidermalgrowthfactoregflevelsananimalstudy AT rabia evaluationofacutewoundhealingpotentialofreddragonfruithylocereuspolyrhizusextractcreamontypeiiicollagenandepidermalgrowthfactoregflevelsananimalstudy AT yulianasyam evaluationofacutewoundhealingpotentialofreddragonfruithylocereuspolyrhizusextractcreamontypeiiicollagenandepidermalgrowthfactoregflevelsananimalstudy |