Videodensitometric Methods for Cardiac Output Measurements
Cardiac output is often measured by indicator dilution techniques, usually based on dye or cold saline injections. Developments of more stable ultrasound contrast agents (UCA) are leading to new noninvasive indicator dilution methods. However, several problems concerning the interpretation of diluti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2003-04-01
|
| Series: | EURASIP Journal on Advances in Signal Processing |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1155/S1110865703211185 |
| _version_ | 1818490612546011136 |
|---|---|
| author | Massimo Mischi Erik Korsten Ton Kalker |
| author_facet | Massimo Mischi Erik Korsten Ton Kalker |
| author_sort | Massimo Mischi |
| collection | DOAJ |
| description | Cardiac output is often measured by indicator dilution techniques, usually based on dye or cold saline injections. Developments of more stable ultrasound contrast agents (UCA) are leading to new noninvasive indicator dilution methods. However, several problems concerning the interpretation of dilution curves as detected by ultrasound transducers have arisen. This paper presents a method for blood flow measurements based on UCA dilution. Dilution curves are determined by real-time densitometric analysis of the video output of an ultrasound scanner and are automatically fitted by the Local Density Random Walk model. A new fitting algorithm based on multiple linear regression is developed. Calibration, that is, the relation between videodensity and UCA concentration, is modelled by in vitro experimentation. The flow measurement system is validated by in vitro perfusion of SonoVue contrast agent. The results show an accurate dilution curve fit and flow estimation with determination coefficient larger than 0.95 and 0.99, respectively. |
| first_indexed | 2024-12-10T17:19:19Z |
| format | Article |
| id | doaj.art-3b8d50bb76f447b38eeb3fb2f6c46cc3 |
| institution | Directory Open Access Journal |
| issn | 1687-6172 1687-6180 |
| language | English |
| last_indexed | 2024-12-10T17:19:19Z |
| publishDate | 2003-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EURASIP Journal on Advances in Signal Processing |
| spelling | doaj.art-3b8d50bb76f447b38eeb3fb2f6c46cc32022-12-22T01:40:02ZengSpringerOpenEURASIP Journal on Advances in Signal Processing1687-61721687-61802003-04-012003547948910.1155/S1687617203211185Videodensitometric Methods for Cardiac Output MeasurementsMassimo MischiErik KorstenTon KalkerCardiac output is often measured by indicator dilution techniques, usually based on dye or cold saline injections. Developments of more stable ultrasound contrast agents (UCA) are leading to new noninvasive indicator dilution methods. However, several problems concerning the interpretation of dilution curves as detected by ultrasound transducers have arisen. This paper presents a method for blood flow measurements based on UCA dilution. Dilution curves are determined by real-time densitometric analysis of the video output of an ultrasound scanner and are automatically fitted by the Local Density Random Walk model. A new fitting algorithm based on multiple linear regression is developed. Calibration, that is, the relation between videodensity and UCA concentration, is modelled by in vitro experimentation. The flow measurement system is validated by in vitro perfusion of SonoVue contrast agent. The results show an accurate dilution curve fit and flow estimation with determination coefficient larger than 0.95 and 0.99, respectively.http://dx.doi.org/10.1155/S1110865703211185contrast agentslocal density random walkultrasoundvideodensitometry. |
| spellingShingle | Massimo Mischi Erik Korsten Ton Kalker Videodensitometric Methods for Cardiac Output Measurements EURASIP Journal on Advances in Signal Processing contrast agents local density random walk ultrasound videodensitometry. |
| title | Videodensitometric Methods for Cardiac Output Measurements |
| title_full | Videodensitometric Methods for Cardiac Output Measurements |
| title_fullStr | Videodensitometric Methods for Cardiac Output Measurements |
| title_full_unstemmed | Videodensitometric Methods for Cardiac Output Measurements |
| title_short | Videodensitometric Methods for Cardiac Output Measurements |
| title_sort | videodensitometric methods for cardiac output measurements |
| topic | contrast agents local density random walk ultrasound videodensitometry. |
| url | http://dx.doi.org/10.1155/S1110865703211185 |
| work_keys_str_mv | AT massimomischi videodensitometricmethodsforcardiacoutputmeasurements AT erikkorsten videodensitometricmethodsforcardiacoutputmeasurements AT tonkalker videodensitometricmethodsforcardiacoutputmeasurements |