Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

Abstract Background Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to anti-EGFR monoclonal antibodies in KRAS-wild type colorectal cancer (CRC), while the same combination reverts anti-EGFR primary...

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Bibliographic Details
Main Authors: Pietro Paolo Vitiello, Claudia Cardone, Giulia Martini, Davide Ciardiello, Valentina Belli, Nunzia Matrone, Giusi Barra, Stefania Napolitano, Carmina Della Corte, Mimmo Turano, Maria Furia, Teresa Troiani, Floriana Morgillo, Ferdinando De Vita, Fortunato Ciardiello, Erika Martinelli
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Tumor cell biology
Epidermal growth factor receptor (EGFR)
RAS mutation
MAPK pathway
PI3K pathway
Online Access:http://link.springer.com/article/10.1186/s13046-019-1035-0

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