Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis.
Several studies highlight the role of inflammatory markers in thrombosis as well as in cancer. However, their combined role in cancer-associated deep vein thrombosis (DVT) and the molecular mechanisms, involved in its pathophysiology, needs further investigations. In the present study, C-reactive pr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4507873?pdf=render |
| _version_ | 1828961789514088448 |
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| author | Grazia Malaponte Salvatore S Signorelli Valentina Bevelacqua Jerry Polesel Martina Taborelli Claudio Guarneri Concettina Fenga Kazou Umezawa Massimo Libra |
| author_facet | Grazia Malaponte Salvatore S Signorelli Valentina Bevelacqua Jerry Polesel Martina Taborelli Claudio Guarneri Concettina Fenga Kazou Umezawa Massimo Libra |
| author_sort | Grazia Malaponte |
| collection | DOAJ |
| description | Several studies highlight the role of inflammatory markers in thrombosis as well as in cancer. However, their combined role in cancer-associated deep vein thrombosis (DVT) and the molecular mechanisms, involved in its pathophysiology, needs further investigations. In the present study, C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1β), matrix metalloproteases-9 (MMP-9), vascular endothelial growth factor (VEGF), tissue factor (TF), fibrinogen and soluble P-selectin, were analyzed in plasma and in monocyte samples from 385 cancer patients, of whom 64 were concomitantly affected by DVT (+). All these markers were higher in cancer patients DVT+ than in those DVT-. Accordingly, significantly higher NF-kB activity was observed in cancer patients DVT+ than DVT-. Significant correlation between data obtained in plasma and monocyte samples was observed. NF-kB inhibition was associated with decreased levels of all molecules in both cancer DVT+ and DVT-. To further demonstrate the involvement of NF-kB activation by the above mentioned molecules, we treated monocyte derived from healthy donors with a pool of sera from cancer patients with and without DVT. These set of experiments further suggest the significant role played by some molecules, regulated by NF-kB, and detected in cancer patients with DVT. Our data support the notion that NF-kB may be considered as a therapeutic target for cancer patients, especially those complicated by DVT. Treatment with NF-kB inhibitors may represent a possible strategy to prevent or reduce the risk of DVT in cancer patients. |
| first_indexed | 2024-12-14T09:52:07Z |
| format | Article |
| id | doaj.art-3b8dab5623f547b69b1600deae6f3f8a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T09:52:07Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b8dab5623f547b69b1600deae6f3f8a2022-12-21T23:07:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013249610.1371/journal.pone.0132496Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis.Grazia MalaponteSalvatore S SignorelliValentina BevelacquaJerry PoleselMartina TaborelliClaudio GuarneriConcettina FengaKazou UmezawaMassimo LibraSeveral studies highlight the role of inflammatory markers in thrombosis as well as in cancer. However, their combined role in cancer-associated deep vein thrombosis (DVT) and the molecular mechanisms, involved in its pathophysiology, needs further investigations. In the present study, C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1β), matrix metalloproteases-9 (MMP-9), vascular endothelial growth factor (VEGF), tissue factor (TF), fibrinogen and soluble P-selectin, were analyzed in plasma and in monocyte samples from 385 cancer patients, of whom 64 were concomitantly affected by DVT (+). All these markers were higher in cancer patients DVT+ than in those DVT-. Accordingly, significantly higher NF-kB activity was observed in cancer patients DVT+ than DVT-. Significant correlation between data obtained in plasma and monocyte samples was observed. NF-kB inhibition was associated with decreased levels of all molecules in both cancer DVT+ and DVT-. To further demonstrate the involvement of NF-kB activation by the above mentioned molecules, we treated monocyte derived from healthy donors with a pool of sera from cancer patients with and without DVT. These set of experiments further suggest the significant role played by some molecules, regulated by NF-kB, and detected in cancer patients with DVT. Our data support the notion that NF-kB may be considered as a therapeutic target for cancer patients, especially those complicated by DVT. Treatment with NF-kB inhibitors may represent a possible strategy to prevent or reduce the risk of DVT in cancer patients.http://europepmc.org/articles/PMC4507873?pdf=render |
| spellingShingle | Grazia Malaponte Salvatore S Signorelli Valentina Bevelacqua Jerry Polesel Martina Taborelli Claudio Guarneri Concettina Fenga Kazou Umezawa Massimo Libra Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. PLoS ONE |
| title | Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. |
| title_full | Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. |
| title_fullStr | Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. |
| title_full_unstemmed | Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. |
| title_short | Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. |
| title_sort | increased levels of nf kb dependent markers in cancer associated deep venous thrombosis |
| url | http://europepmc.org/articles/PMC4507873?pdf=render |
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