Phenyl glycine incorporated glitazones as promising novel antidiabetic agents through PPARγ agonism: Design, synthesis and preclinical studies
Nuclear receptors function as regulators in different anabolic and catabolic pathways. PPARγ, a superfamily of nuclear receptors take part in glucose and lipid metabolism. The functional activation of PPARγ enhances insulin sensitization thereby enhances glucose uptake which results in antidiabetic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417422000395 |