Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study
ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications,...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2022-05-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005009203&lng=en&tlng=en |
| _version_ | 1818186925286096896 |
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| author | Fırat Erdoğan Evrim Şenkal Ömer Faruk Özer İlke Özahi İpek Şükriye Leyla Altuntaş Şükriye Özde |
| author_facet | Fırat Erdoğan Evrim Şenkal Ömer Faruk Özer İlke Özahi İpek Şükriye Leyla Altuntaş Şükriye Özde |
| author_sort | Fırat Erdoğan |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation. |
| first_indexed | 2024-12-11T23:02:53Z |
| format | Article |
| id | doaj.art-3b8f95db133b4fdb9d12a89efed9713f |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-11T23:02:53Z |
| publishDate | 2022-05-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-3b8f95db133b4fdb9d12a89efed9713f2022-12-22T00:47:01ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602022-05-0110.1590/1516-3180.2021.0209.r1.25082021Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective studyFırat Erdoğanhttps://orcid.org/0000-0002-6299-7067Evrim Şenkalhttps://orcid.org/0000-0002-3075-2348Ömer Faruk Özerhttps://orcid.org/0000-0002-9034-4805İlke Özahi İpekhttps://orcid.org/0000-0002-9120-7642Şükriye Leyla Altuntaşhttps://orcid.org/0000-0003-1985-552XŞükriye Özdehttps://orcid.org/0000-0002-0053-6222ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005009203&lng=en&tlng=enDiabetes mellitus, gestationalStress, oxidativeAntioxidantsGestational diabetes mellitusOxidative stress indexTotal antioxidant capacityTotal oxidant status |
| spellingShingle | Fırat Erdoğan Evrim Şenkal Ömer Faruk Özer İlke Özahi İpek Şükriye Leyla Altuntaş Şükriye Özde Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study São Paulo Medical Journal Diabetes mellitus, gestational Stress, oxidative Antioxidants Gestational diabetes mellitus Oxidative stress index Total antioxidant capacity Total oxidant status |
| title | Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
| title_full | Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
| title_fullStr | Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
| title_full_unstemmed | Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
| title_short | Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
| title_sort | oxidative stress in maternal milk and cord blood in gestational diabetes mellitus a prospective study |
| topic | Diabetes mellitus, gestational Stress, oxidative Antioxidants Gestational diabetes mellitus Oxidative stress index Total antioxidant capacity Total oxidant status |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005009203&lng=en&tlng=en |
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