Cerebral Vasodilator Property of Poly(ADP-Ribose) Polymerase Inhibitor (PJ34) in the Neonatal and Adult Mouse Is Mediated by the Nitric Oxide Pathway

Cerebral Vasodilator Property of Poly(ADP-Ribose) Polymerase Inhibitor (PJ34) in the Neonatal and Adult Mouse Is Mediated by the Nitric Oxide Pathway

The poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 has been reported to improve endothelial dysfunction in the peripheral system. We addressed the role of PJ34 on the vascular tone and vasoreactivity during development in the mouse brain. Blood flows were measured in the basilar trunk using ultra...

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Bibliographic Details
Main Authors: Philippe Bonnin, Christiane Charriaut-Marlangue, Julien Pansiot, Alexandre Boutigny, Jean-Marie Launay, Valérie C. Besson
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
cerebral blood flow
cerebral vasoreactivity
arterial dilation
mouse
brain
no synthase
Online Access:https://www.mdpi.com/1422-0067/21/18/6569

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